ArticleClinical and experimental emergency medicine2023
Targeted temperature management with hypothermia for comatose patients after cardiac arrest.
Article in Clinical and experimental emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Case Volume of Targeted Temperature Management and Neurological Outcomes in Comatose Out-of-Hospital Cardiac Arrest Survivors: Nationwide Population-Based Study.Korean circulation journal · 2026Article
- Mitochondrial DNA-Mediated Immune Activation After Resuscitation From Cardiac Arrest.Journal of the American Heart Association · 2026Article
- Stress hyperglycemia ratio is associated with neurological outcome after cardiac arrest.Scientific reports · 2025Article
- Tailoring Targeted Temperature Management in Comatose Out-of-Hospital Cardiac Arrest Survivors: A Retrospective Analysis Based on the rCAST Score Classification.Journal of clinical medicine · 2025Article
- Pharmacotherapy variability and precision medicine in neurocritical care.Frontiers in neurology · 2025Review
- Article
- Differential Effects of Targeted Temperature Management on Sex-Dependent Outcomes After Experimental Asphyxial Cardiac Arrest.Therapeutic hypothermia and temperature management · 2024Article
- Alteration in cerebrospinal fluid flow based on the neurological prognosis of out-of-hospital cardiac arrest patients.Scientific reports · 2024Observational
- Therapeutic hypothermia is not dead, but hibernating!Clinical and experimental emergency medicine · 2024Article
- Characterization of Circulating Cold Shock Proteins FGF21 and RBM3 in a Multi-Center Study of Pediatric Cardiac Arrest.Therapeutic hypothermia and temperature management · 2024Article
- Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest.Medicina (Kaunas, Lithuania) · 2024Review
- Distribution and elimination kinetics of midazolam and metabolites after post-resuscitation care: a prospective observational study.Scientific reports · 2024Observational
- Navigating the 'Triangle of Death': A Multidisciplinary Approach in Severe Multi-Trauma Management.Clinical medicine insights. Case reports · 2024Article
- Temperature control after cardiac arrest.Resuscitation · 2023Review
- Preliminary Prognostication for Good Neurological Outcomes in the Early Stage of Post-Cardiac Arrest Care.Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Targeted temperature management with mild hypothermia (TTM-hypothermia; 32-34 °C) is a treatment strategy for adult patients who are comatose after cardiac arrest. Robust preclinical data support the beneficial effects of hypothermia beginning within 4 hours of reperfusion and maintained during the several days of postreperfusion brain dysregulation. TTM-hypothermia increased survival and functional recovery after adult cardiac arrest in several trials and in realworld implementation studies. TTM-hypothermia also benefits neonates with hypoxic-ischemic brain injury. However, larger and methodologically more rigorous adult trials do not detect benefit. Reasons for inconsistency of adult trials include the difficulty delivering differential treatment between randomized groups within 4 hours and the use of shorter durations of treatment. Furthermore, adult trials enrolled populations that vary in illness severity and brain injury, with individual trials enriched for higher or lower illness severity. There are interactions between illness severity and treatment effect. Current data indicate that TTM-hypothermia implemented quickly for adult patients after cardiac arrest, may benefit select patients at risk of severe brain injury but not benefit other patients. More data are needed on how to identify treatment-responsive patients and on how to titrate the timing and duration of TTM-hypothermia.
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Registered trials
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