Evidence map›Paper›PMID 36796762›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023

Mutations in latent membrane protein 1 of Epstein-Barr virus are associated with increased risk of posttransplant lymphoproliferative disorder in children.

Olivia M Martinez, Sheri M Krams, Mark A Robien, Mary G Lapasaran, Matthew P Arvedson, Andrea Reitsma, Yarl Balachandran, Aleishia Harris-Arnold, Kenneth Weinberg, Scott D Boyd and 14 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02182986 (Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02182986 completednot on this map

Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children (CTOTC-06)

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2014 to 2019Enrolled944ConditionsHeart Transplant, Small Intestine Transplant, Kidney Transplant, Liver TransplantArmstransplant, Immunosuppressive Drugs
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Predictive biomarkers and preventive strategies for PTLD: a turning point in viro-immunologic precision medicine?Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 1 country.

Olivia M MartinezDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA; Stanford Immunology, Stanford University School of Medicine, Palo Alto, California, USA. Electronic address: omm@stanford.edu.
Sheri M KramsDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA; Stanford Immunology, Stanford University School of Medicine, Palo Alto, California, USA.
Mark A RobienNational Institute of Allergy and Infectious Disease, Rockville, Maryland, USA.
Mary G LapasaranDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Matthew P ArvedsonDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Andrea ReitsmaDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Yarl BalachandranDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Aleishia Harris-ArnoldDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA; Stanford Immunology, Stanford University School of Medicine, Palo Alto, California, USA.
Kenneth WeinbergDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Scott D BoydDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Brian ArmstrongRho, Durham, North Carolina, USA.
Amber TrickeyDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Clare J TwistRoswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Dita GratzingerDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Brent TanDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Merideth BrownNational Institute of Allergy and Infectious Disease, Rockville, Maryland, USA.
Clifford ChinDepartment of Pediatrics and Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, Ohio, USA.
Dev M DesaiUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
Thomas M FishbeinDepartments of Surgery and Pediatrics, MedStar Georgetown University Hospital, Georgetown, Washington, DC, USA.
George V MazariegosUniversity of Pittsburgh Medical Center, Children's Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Akin TekinMiller School of Medicine, University of Medicine, Florida, USA.
Robert S VenickDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Daniel BernsteinDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Carlos O EsquivelDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Stanford University · USPalo Alto University · USNational Institute of Allergy and Infectious Diseases · USChildren's Hospital of Pittsburgh · USCincinnati Children's Hospital Medical Center · USGeorgetown University · USRoswell Park Comprehensive Cancer Center · USThe University of Texas Southwestern Medical Center · USUniversity of California, Los Angeles · US

Funding

Transplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1M
Biomarkers for Post-Transplant Lymphoproliferative Disorders in ChildrenU01AI104342 · NIAID · STANFORD UNIVERSITY · PI ESQUIVEL, CARLOS O · 2013 to 2018
$7.7M
RhoFED T-SCCCU01AI178768 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI ARMSTRONG, BRIAN · 2023 to 2023
$1.5M
NIAID NIH HHS U01 AI104342NIAID NIH HHS U01 AI178768NIAID NIH HHS UM2 AI117870
6 · The paper itself

Abstract

Epstein-Barr virus (EBV)-positive posttransplant lymphoproliferative disorder (PTLD) results in significant morbidity and mortality in pediatric transplant recipients. Identifying individuals at an increased risk of EBV-positive PTLD could influence clinical management of immunosuppression and other therapies, improving posttransplant outcomes. A 7-center prospective, observational clinical trial of 872 pediatric transplant recipients evaluated the presence of mutations at positions 212 and 366 of EBV latent membrane protein 1 (LMP1) as an indicator of risk of EBV-positive PTLD (clinical trials: NCT02182986). DNA was isolated from peripheral blood of EBV-positive PTLD case patients and matched controls (1:2 nested case:control), and the cytoplasmic tail of LMP1 was sequenced. Thirty-four participants reached the primary endpoint of biopsy-proven EBV-positive PTLD. DNA was sequenced from 32 PTLD case patients and 62 matched controls. Both LMP1 mutations were present in 31 of 32 PTLD cases (96.9%) and in 45 of 62 matched controls (72.6%) (P = .005; OR = 11.7; 95% confidence interval, 1.5, 92.6). The presence of both G212S and S366T carries a nearly 12-fold increased risk of development of EBV-positive PTLD. Conversely, transplant recipients without both LMP1 mutations carry a very low risk of PTLD. Analysis of mutations at positions 212 and 366 of LMP1 can be informative in stratifying patients for risk of EBV-positive PTLD.

Indexed as

Epstein-Barr Virus InfectionsLymphoproliferative DisordersChildHerpesvirus 4, HumanHumansMembrane ProteinsMutationProspective StudiesMembrane ProteinsB cell lymphomaEBVLMP1pediatric transplantationPTLD

Identifiers

PMID36796762
PMCPMC10159954
OpenAlexW4320921274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.