Evidence map›Paper›PMID 36796513›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023

Associations Between Cognitive and Physical Effort-Based Decision Making in People With Schizophrenia and Healthy Control Subjects.

Adam J Culbreth, Sally D Dershwitz, Deanna M Barch, Erin K Moran

Open access · greenAbstract read
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2025
    Article
  4. Day-to-day fluctuations in motivation drive effort-based decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Social Effort Discounting Reveals Domain-General and Social-Specific Motivation Components.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Article
  6. Article
  7. Cognitive Control in Schizophrenia: Advances in Computational Approaches.Current directions in psychological science · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Adam J CulbrethMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, School of Medicine, Baltimore, Maryland. Electronic address: aculbreth@som.umaryland.edu.
Sally D DershwitzDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri.
Deanna M BarchDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri; Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Erin K MoranDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Washington University in St. Louis · USUniversity of Maryland, Baltimore · US

Funding

Effort-Based Decision Making and Motivated Behavior in Everyday LifeR37MH066031 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch · 2018 to 2026
$6.5M
Multidisciplinary Schizophrenia Research TrainingT32MH067533 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CARPENTER, WILLIAM T., ELMER, GREGORY I · 2004 to 2025
$4.3M
Computational Mechanisms of Effort-Cost Decision-Making in SchizophreniaK23MH126986 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CULBRETH, ADAM J. · 2021 to 2025
$827k
NIMH NIH HHS K23 MH126986NIMH NIH HHS R37 MH066031NIMH NIH HHS T32 MH067533
6 · The paper itself

Abstract

backgroundEffort can take a variety of forms including physical (e.g., button pressing) and cognitive (e.g., working memory tasks). Few studies have examined whether individual differences in willingness to expend effort are similar or different across modalities.

methodsWe recruited 30 individuals with schizophrenia and 44 healthy control subjects to complete 2 effort-cost decision-making tasks: the Effort Expenditure for Rewards Task (physical effort) and the cognitive effort discounting task (cognitive effort).

resultsWillingness to expend cognitive and physical effort was positively associated for both individuals with schizophrenia and control subjects. Further, we found that individual differences in motivation and pleasure dimension of negative symptoms modulated the association between physical and cognitive effort. Specifically, participants with lower motivation and pleasure scores, irrespective of group status, showed stronger associations between task measures of cognitive and physical effort-cost decision making.

conclusionsThese results suggest a generalized deficit across effort modalities in individuals with schizophrenia. Further, reductions in motivation and pleasure may impact effort-cost decision making in a domain-general manner.

Indexed as

SchizophreniaCognitionDecision MakingHumansPhysical ExertionRewardCognitionEffort-cost decision makingExperimental psychopathologyMotivationReward processingSchizophrenia

Identifiers

PMID36796513
PMCPMC10330111
OpenAlexW4320712501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.