Evidence map›Paper›PMID 36796007›Full record

ArticleBiomacromolecules2023

Exploring the Extreme Acid Tolerance of a Dynamic Protein Nanocage.

Jesse A Jones, Michael P Andreas, Tobias W Giessen

Open access · greenAbstract read
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Encapsulins: catalysis inside a shell.Current opinion in microbiology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. The Structural Diversity of Encapsulin Protein Shells.Chembiochem : a European journal of chemical biology · 2024
    Review
  9. Structural Characterization ofMicroorganisms · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Structure and heterogeneity of a highly cargo-loaded encapsulin shell.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jesse A JonesDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0624, United States.ORCID 0000-0001-8006-5661
Michael P AndreasDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0624, United States.ORCID 0000-0001-8871-3053
Tobias W GiessenDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0624, United States.ORCID 0000-0001-6328-2031
University of Michigan · US

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Protein Organelles In Human-Associated BacteriaR35GM133325 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Tobias Wolfgang Giessen · 2019 to 2026
$3.8M
NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R35 GM133325
6 · The paper itself

Abstract

Encapsulins are microbial protein nanocages capable of efficient self-assembly and cargo enzyme encapsulation. Due to their favorable properties, including high thermostability, protease resistance, and robust heterologous expression, encapsulins have become popular bioengineering tools for applications in medicine, catalysis, and nanotechnology. Resistance against physicochemical extremes like high temperature and low pH is a highly desirable feature for many biotechnological applications. However, no systematic search for acid-stable encapsulins has been carried out, while the influence of pH on encapsulin shells has so far not been thoroughly explored. Here, we report on a newly identified encapsulin nanocage from the acid-tolerant bacterium

Indexed as

BacteriaBacterial ProteinsBiotechnologyCryoelectron MicroscopyNanotechnologyBacterial Proteins

Identifiers

PMID36796007
PMCPMC10311355
OpenAlexW4321018860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.