Evidence map›Paper›PMID 36795286›Full record

ArticleJournal of cardiovascular translational research2024

Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction.

Koen W Streng, Hans L Hillege, Jozine M Ter Maaten, Dirk J van Veldhuisen, Kenneth Dickstein, Nilesh J Samani, Leong L Ng, Marco Metra, Gerasimos S Filippatos, Piotr Ponikowski and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Heart Failure: Is There an Ideal Biomarker?Reviews in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Koen W StrengDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.ORCID 0000-0002-0484-5268
Hans L HillegeDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Jozine M Ter MaatenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Dirk J van VeldhuisenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Kenneth DicksteinUniversity of Bergen, 5007, Bergen, Norway.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.
Leong L NgDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.
Marco MetraInstitute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Gerasimos S FilippatosAttikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Piotr PonikowskiDepartment of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Faiez ZannadINSERM, Centre d'Investigations Cliniques Plurithe´Matique 1433, F-CRIN INI-CRCT, INSERM U1116, Universite´ de Lorraine, CHRU de Nancy, Nancy, France.
Stefan D AnkerDivision of Cardiology and Metabolism, Department of Cardiology (CVK) and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.
Peter van der MeerDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Chim C LangDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, DD1 9SY, Dundee, Scotland.
Adriaan A VoorsDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. a.a.voors@umcg.nl.
Kevin DammanDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.

Funding

FP7 Ideas: European Research Council FP7-242209-BIOSTAT-CHFHartstichting [CVON2014-11 RECONNECT
6 · The paper itself

Abstract

backgroundRecent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting different nephron segments in heart failure patients.

methodsIn 2070, in chronic heart failure patients, we measured several established and upcoming urinary markers reflecting different nephron segments.

resultsMean age was 70 ± 12 years, 74% was male and 81% (n = 1677) had HFrEF. Mean estimated glomerular filtration rate (eGFR) was lower in patients with HFpEF (56 ± 23 versus 63 ± 23 ml/min/1.73 m

conclusionsHFpEF patients showed more evidence of tubular damage and/or dysfunction compared with HFrEF patients, in particular when glomerular function was preserved.

Indexed as

Heart FailureAgedAged, 80 and overChronic DiseaseGlomerular Filtration RateHumansMaleMiddle AgedPrognosisStroke VolumeHeart failureProximal tubuleRenal functionUrinary markers

Identifiers

PMID36795286
PMCPMC10896953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.