Evidence map›Paper›PMID 36795281›Full record

Trial reportInternational journal of clinical oncology2023

Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer.

Takahito Kondo, Kiyoaki Tsukahara, Daisuke Kawakita, Seiichi Yoshimoto, Kouki Miura, Masashi Sugasawa, Kazuaki Chikamatsu, Takashi Matsuzuka, Isao Oze, Morimasa Kitamura and 10 more

Abstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase III
PubMed Publisher
In one paragraph

Trial report in International journal of clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Prognostic impact of micrometastases and nodal status in early and advanced oral squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 18 institutions in 1 country.

Takahito KondoDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji-shi, Tokyo, 193-0998, Japan.ORCID http://orcid.org/0000-0001-9323-3003
Kiyoaki TsukaharaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. tsuka@tokyo-med.ac.jp.ORCID http://orcid.org/0000-0002-4198-9615
Daisuke KawakitaDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya-shi, Aichi, 467-8601, Japan.ORCID http://orcid.org/0000-0003-3794-2790
Seiichi YoshimotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Kouki MiuraDepartment of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo, 108-8329, Japan.
Masashi SugasawaDepartment of Head and Neck Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1298, Japan.
Kazuaki ChikamatsuDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-cho, Maebashi-shi, Gunma, 371-8511, Japan.
Takashi MatsuzukaDepartment of Head and Neck Surgery-Otolaryngology, Asahi University Hospital, 3-23 Hashimoto-cho, Gifu-shi, Gifu, 500-8523, Japan.
Isao OzeDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya-shi, Aichi, 464-8681, Japan.
Morimasa KitamuraDepartment of Head and Neck Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada-cho, Kahoku-gun, Ishikawa, 920-0293, Japan.
Yoshiko MurakamiDepartment of Pathological Diagnosis, Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya-shi, Aichi, 460-0001, Japan.
Shinji OtozaiDepartment of Head and Neck Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka-shi, Osaka, 541-8567, Japan.
Takeshi ShinozakiDepartment of Head and Neck Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba, 277-8577, Japan.
Shinichi OhbaDepartment of Otorhinolaryngology, Juntendo University Faculty of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.
Koji ArakiDepartment of Otolaryngology-Head and Neck Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama, 359-8513, Japan.
Takatsugu MizumachiDepartment of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 14, Nishi 5, Kita-ku, Sapporo-shi, Hokkaido, 060-8648, Japan.
Dai SatoDepartment of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.
Naohiro WakisakaDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa-shi, Ishikawa, 920-8641, Japan.
Hitoshi HirakawaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Nakagami-gun, Okinawa, 903-0215, Japan.
Yasuhisa HasegawaDepartment of Head and Neck Surgery-Otolaryngology, Asahi University Hospital, 3-23 Hashimoto-cho, Gifu-shi, Gifu, 500-8523, Japan.
Asahi University · JPAichi Cancer Center · JPGunma University · JPHokkaido University · JPJuntendo University · JPKanazawa Medical University · JPKanazawa University · JPKyorin University · JPMita Hospital · JPNagoya City University · JPNagoya Medical Center · JPNational Cancer Center Hospital East · JPNational Defense Medical College · JPOsaka International Cancer Institute · JPSaitama Medical University · JPTokyo Medical University · JPTokyo Medical University Hachioji Medical Center · JPUniversity of the Ryukyus · JP

Funding

Ministry of Health, Labour and Welfare H21-Gannrinshou-Ippan-016Ministry of Health, Labour and Welfare H24-Gannrinshou-Ippan-006
6 · The paper itself

Abstract

backgroundA multicenter, randomized controlled phase III trial was conducted on sentinel lymph node biopsy (SLNB) and elective neck dissection for T1 (depth of invasion ≥ 4 mm)-T2N0M0 oral cavity squamous cell carcinoma. This study identified factors associated with poor prognosis in patients who underwent SLNB based on a subgroup analysis of this trial.

methodsWe analyzed 418 sentinel lymph nodes (SLNs) from 132 patients who underwent SLNB. The metastatic SLNs were classified into three categories based on size-isolated tumor cells: < 0.2 mm, micrometastasis: ≥ 0.2 mm and < 2 mm, and macrometastasis: ≥ 2 mm. Three groups were formed based on the number of metastatic SLNs: no metastasis, 1 metastatic node, and ≥ 2 metastatic nodes. The size and number of metastatic SLNs on survival were evaluated using Cox proportional hazard models.

resultsPatients with macrometastasis and ≥ 2 metastatic SLNs had worse overall survival (OS) and disease-free survival (DFS) after adjustment for potential confounders (HR for OS: macrometastasis, 4.85; 95% CI 1.34-17.60; ≥ 2 metastatic SLN, 3.63; 95% CI 1.02-12.89; HR for DFS: macrometastasis, 2.94; 95% CI 1.16-7.44; ≥ 2 metastatic SLN, 2.97; 95% CI 1.18-7.51).

conclusionsIn patients who underwent SLNB, a poorer prognosis was associated with macrometastasis or having ≥ 2 metastatic SLNs.

Indexed as

Mouth NeoplasmsSentinel Lymph NodeDisease-Free SurvivalFemaleHumansLymphatic MetastasisLymph NodesNeck DissectionSentinel Lymph Node BiopsyNeck dissectionOral cancerSentinel lymph node

Identifiers

PMID36795281
OpenAlexW4321004106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.