ArticleBehavior genetics2023
Gene-by-Environment Interaction Effects of Social Adversity on Externalizing Behavior in ABCD Youth.
Article in Behavior genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Effects of working memory and reward reactivity on externalizing behaviors in the ABCD study.Developmental cognitive neuroscience · 2026Article
- From school climate to brain development: What the ABCD study reveals about the educational context of adolescence.Developmental cognitive neuroscience · 2026Review
- Assessing the Psychometric Properties of the Child Behaviour Checklist in the ABCD Study.Developmental science · 2026Article
- Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Neighborhood context, genetic influences, and life satisfaction: Evidence from the German twin family panel.PloS one · 2025Article
- Differential etiologic associations of heroin use and prescription opioid misuse with psychopathology.Journal of psychopathology and clinical science · 2024Article
- Gene-environment interaction between gaming addiction and perceived stress in late adolescents and young adults: A twin study.Journal of behavioral addictions · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This study tested whether multiple domains of social adversity, including neighborhood opportunity/deprivation and life stress, moderate genetic (A), common environmental (C), and unique environmental (E) influences on externalizing behaviors in 760 same-sex twin pairs (332 monozygotic; 428 dizygotic) ages 10-11 from the ABCD Study. Proportion of C influences on externalizing behavior increased at higher neighborhood adversity (lower overall opportunity). A decreased and C and E increased at lower levels of educational opportunity. A increased at lower health-environment and social-economic opportunity levels. For life stress, A decreased and E increased with number of experienced events. Results for educational opportunity and stressful life experiences suggest a bioecological gene-environment interaction pattern such that environmental influences predominate at higher levels of adversity, whereas limited access to healthcare, housing, and employment stability may potentiate genetic liability for externalizing behavior via a diathesis-stress mechanism. More detailed operationalization of social adversity in gene-environment interaction studies is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.