Evidence map›Paper›PMID 36795250›Full record

SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2023

Predictors of marginal ulcer after gastric bypass: a systematic review and meta-analysis.

Azizullah Beran, Mohammad Shaear, Saif Al-Mudares, Ishna Sharma, Reem Matar, Mohammad Al-Haddad, Marita Salame, Ray Portela, Benjamin Clapp, Barham K Abu Dayyeh and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Azizullah BeranDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.
Mohammad ShaearDepartment of General Surgery, College of Medicine, Central Michigan University, Saginaw, MI, USA.
Saif Al-MudaresDepartment of Surgery, University of Mississippi Medical Center, Jackson, MS, USA.
Ishna SharmaDepartment of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Reem MatarDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Mohammad Al-HaddadDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.
Marita SalameDepartment of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Ray PortelaDepartment of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Benjamin ClappDepartment of Surgery, Texas Tech University, El Paso, TX, USA.
Barham K Abu DayyehDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Omar M GhanemDepartment of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Ghanem.omar@mayo.edu.ORCID 0000-0002-5725-8497
Mayo Clinic · USIndiana University School of MedicineMayo Clinic in Arizona · USCentral Michigan University · USJackson Memorial Hospital · USTexas Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMarginal ulcer (MU) is a common complication following Roux-en-Y gastric bypass (RYGB) with an incidence rate of up to 25%. Several studies have evaluated different risk factors associated with MU with inconsistent findings. In this meta-analysis, we aimed to identify the predictors of MU after RYGB.

methodsA comprehensive literature search of PubMed, Embase, and Web of Science databases was conducted through April 2022. All studies that used a multivariate model to assess risk factors for MU after RYGB were included. Pooled odds ratios (OR) with 95% confidence intervals (CI) for risk factors reported in ≥ 3 studies were obtained within a random-effects model.

resultsFourteen studies with 344,829 patients who underwent RYGB were included. Eleven different risk factors were analyzed. Meta-analysis demonstrated that Helicobacter pylori (HP) infection (OR 4.97 [2.24-10.99]), smoking (OR 2.50 [1.76-3.54]), and diabetes mellitus (OR 1.80 [1.15-2.80]), were significant predictors of MU. Increased age, body mass index, female gender, obstructive sleep apnea, hypertension, and alcohol use were not predictors of MU. There was a trend of an increased risk of MU associated with nonsteroidal anti-inflammatory drugs (OR 2.43 [0.72-8.21]) and a lower risk of MU with proton pump inhibitors use (OR 0.44 [0.11-2.11]).

conclusionsSmoking cessation, optimizing glycemic control, and eradication of HP infection reduce the risk of MU following RYGB. Recognition of predictors of MU after RYGB will allow physicians to identify high-risk patients, improve surgical outcomes, and reduce the risk of MU.

Indexed as

Gastric BypassHypertensionObesity, MorbidPeptic UlcerFemaleHumansProton Pump InhibitorsRetrospective StudiesRisk FactorsProton Pump InhibitorsBariatric surgeryGastric bypassMarginal ulcer

Identifiers

PMID36795250
OpenAlexW4321004547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.