ArticleHealth economics review2023
The economic impact of anastomotic leak after colorectal cancer surgery.
Article in Health economics review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Management of anastomotic leak after elective anterior resection for rectal cancer: A systematic review and pooled analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- The role of remote ischaemic preconditioning (RIPC) in colorectal surgery: a meta-analysis of randomized-controlled studies.Langenbeck's archives of surgery · 2025Pooled it
- Management of anastomotic leak following restorative rectal cancer resection-a multi-centre retrospective audit in Ireland.Irish journal of medical science · 2026Article
- Impact of powered circular stapling devices on anastomotic leakage rates in colorectal surgery.International journal of colorectal disease · 2026Article
- Emergency left side colectomy and primary anastomosis with or without diverting stoma: a comparative study.International journal of colorectal disease · 2026Observational
- Advancing early diagnosis of colorectal anastomotic leakage using drain fluid biochemical analysis.Scientific reports · 2026Article
- Costs associated with anastomotic leak after left-sided colorectal surgery: retrospective real-world study in England.BJS open · 2026Article
- Comparing Wafi ileostomy to Brooke ileostomy in stage 3 rectal cancer: a prospective cohort study.Updates in surgery · 2025Article
- Can 3D Imaging Improve Results in Colorectal Cancer Laparoscopic Surgery?Journal of clinical medicine · 2025Article
- Layer-specific molecular signatures of colon anastomotic healing and leakage in mice.Molecular medicine (Cambridge, Mass.) · 2025Article
- The effects of endoscopic vacuum therapy for non-operative treatment of anastomotic leakage on oncological outcomes in rectal cancer patients.Langenbeck's archives of surgery · 2025Article
- Perioperative assessment of colorectal anastomoses with flexible endoscopy.Updates in surgery · 2025Article
- Incidence of anastomotic leakage using powered circular staplers versus manual circular staplers for left colorectal anastomosis: a cost-effectiveness analysis.Techniques in coloproctology · 2024Observational
- Knockout Genes in Bowel Anastomoses: A Systematic Review of Literature Outcomes.Journal of personalized medicine · 2024Review
- Prophylactic defunctioning stomas improve clinical outcomes of anastomotic leak following rectal cancer resections: An analysis of the US Rectal Cancer Consortium.International journal of colorectal disease · 2024Article
- Successful Clinical Avoidance of Colorectal Anastomotic Leakage through Local Decontamination.Antibiotics (Basel, Switzerland) · 2024Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the economic impact of the incremental consumption of resources for the diagnosis and treatment of anastomotic leak (AL) in patients after resection with anastomosis for colorectal cancer compared to patients without AL on the Spanish health system.
methodThis study included a literature review with parameters validated by experts and the development of a cost analysis model to estimate the incremental resource consumption of patients with AL versus those without. The patients were divided into three groups: 1) colon cancer (CC) with resection, anastomosis and AL; 2) rectal cancer (RC) with resection, anastomosis without protective stoma and AL; and 3) RC with resection, anastomosis with protective stoma and AL.
resultsThe average total incremental cost per patient was €38,819 and €32,599 for CC and RC, respectively. The cost of AL diagnosis per patient was €1018 (CC) and €1030 (RC). The cost of AL treatment per patient in Group 1 ranged from €13,753 (type B) to €44,985 (type C + stoma), that in Group 2 ranged from €7348 (type A) to €44,398 (type C + stoma), and that in Group 3 ranged from €6197 (type A) to €34,414 (type C). Hospital stays represented the highest cost for all groups. In RC, protective stoma was found to minimize the economic consequences of AL.
conclusionsThe appearance of AL generates a considerable increase in the consumption of health resources, mainly due to an increase in hospital stays. The more complex the AL, the higher the cost associated with its treatment. INTEREST OF THE STUDY: it is the first cost-analysis study of AL after CR surgery based on prospective, observational and multicenter studies, with a clear, accepted and uniform definition of AL and estimated over a period of 30 days.
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