ArticlemSphere2023
Comparative Genome Analysis of Enterococcus cecorum Reveals Intercontinental Spread of a Lineage of Clinical Poultry Isolates.
Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Narasin used as a feed additive in conventional rearing of broilers can co-select for vancomycin-resistant Enterococcus faecium through the NarAB ionophore resistance mechanisms.The Journal of antimicrobial chemotherapy · 2026Article
- Genomic characterisation of Enterococcus cecorum isolated from broiler chickens in the United Kingdom.Poultry science · 2026Article
- Differentiating commensal and disease-associatedFrontiers in veterinary science · 2026Article
- Genomic-island cassette architecture provides interpretable signal for exploratory classification of poultry-associatedFrontiers in microbiology · 2026Article
- Modelling the ageing dependence of cancer evolutionary trajectories.Nature reviews. Cancer · 2025Review
- Phenotypic and genomic analysis of the emerging poultry pathogenMicrobial genomics · 2025Article
- Genetic and Environmental Factors Contributing to the Pathogenesis of Vertebral Osteomyelitis Caused byAnimals : an open access journal from MDPI · 2025Review
- Enterococcus species identified by MALDI-TOF MS in milk from dairy cow mastitis cases and herd surveys.Veterinary research communications · 2025Article
- Emergence of linezolid-resistant Enterococcus cecorum clade F harboring optrA/fexA causing enterococcal spondylitis in commercial broilers in China.BMC microbiology · 2025Article
- Invasion of Chicken Intestinal Cells Is Higher forMicroorganisms · 2024Article
- A rare case of invasiveClinical case reports · 2024Article
- The Genetic Landscape of Antimicrobial Resistance Genes inAntibiotics (Basel, Switzerland) · 2024Article
- Molecular Genomic Analyses ofMicroorganisms · 2024Article
- Bacterial chondronecrosis with osteomyelitis lameness in broiler chickens and its implications for welfare, meat safety, and quality: a review.Frontiers in physiology · 2024Review
- Determination of Epidemiological Cutoff Values for Antimicrobial Resistance of Enterococcus cecorum.Journal of clinical microbiology · 2023Article
Corrections and comments
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Authors and funding
24 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterococcus cecorum is an emerging pathogen responsible for osteomyelitis, spondylitis, and femoral head necrosis causing animal suffering and mortality and requiring antimicrobial use in poultry. Paradoxically, E. cecorum is a common inhabitant of the intestinal microbiota of adult chickens. Despite evidence suggesting the existence of clones with pathogenic potential, the genetic and phenotypic relatedness of disease-associated isolates remains little investigated. Here, we sequenced and analyzed the genomes and characterized the phenotypes of more than 100 isolates, the majority of which were collected over the last 10 years from 16 French broiler farms. Comparative genomics, genome-wide association studies, and the measured susceptibility to serum, biofilm-forming capacity, and adhesion to chicken type II collagen were used to identify features associated with clinical isolates. We found that none of the tested phenotypes could discriminate the origin of the isolates or the phylogenetic group. Instead, we found that most clinical isolates are grouped phylogenetically, and our analyses selected six genes that discriminate 94% of isolates associated with disease from those that are not. Analysis of the resistome and the mobilome revealed that multidrug-resistant clones of
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