Evidence map›Paper›PMID 36794754›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1.

Jonathan M Shillingford, James A Shayman

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Multiomics profiling of mouse polycystic kidney disease progression at a single-cell resolution.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Guidelines on antibody use in physiology research.American journal of physiology. Renal physiology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jonathan M ShillingfordDepartment of Internal Medicine, University of Michigan Medical School, University of Michigan, Ann Arbor, Michigan, United States.
James A ShaymanDepartment of Internal Medicine, University of Michigan Medical School, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0003-3230-0190
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Research BaseP30DK090868 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WATNICK, TERRY J · 2010 to 2019
$11.1M
Pilot and Feasibility CoreP30DK106912 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CALVET, JAMES P · 2015 to 2019
$5.5M
NCI NIH HHS P30 CA046592NCI NIH HHS P30 CA168524NIDDK NIH HHS P30 DK090868NIDDK NIH HHS P30 DK106912
6 · The paper itself

Abstract

Polycystic kidney disease is a disorder of renal epithelial growth and differentiation. Transcription factor EB (TFEB), a master regulator of lysosome biogenesis and function, was studied for a potential role in this disorder. Nuclear translocation and functional responses to TFEB activation were studied in three murine models of renal cystic disease, including knockouts of

Indexed as

Polycystic Kidney, Autosomal DominantPolycystic Kidney DiseasesAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCystsDogsFibroblastsHumansMadin Darby Canine Kidney CellsMiceTRPP Cation ChannelsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsTcfeb protein, mouseTFEB protein, humanTRPP Cation Channelsautophagic fluxglycoprotein nonmetastatic melanoma protein Blysosomepolycystic kidneytranscription factor EB

Identifiers

PMID36794754
PMCPMC10069964
OpenAlexW4321003727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.