ArticleAge and ageing2023
Long-term fine particular exposure and incidence of frailty in older adults: findings from the Chinese Longitudinal Healthy Longevity Survey.
Article in Age and ageing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of air pollution and increased risk of frailty.Age and ageing · 2025Pooled it
- Urban exposures, frailty, and mental illness in World Trade Center Health Program responders.Nature communications · 2026Article
- Association between exposure to indoor PMBMC public health · 2026Article
- Community-dwelling older persons' level of functional ability and heat-related vulnerability: results from the Heat-Health Action Plan study in Cologne, Germany.BMC geriatrics · 2026Article
- Extreme temperature events and frailty progression in middle-aged and older adults: the longitudinal evidence from CHARLS.BMC public health · 2026Article
- Air Pollution and the Progression of Physical Function Limitations and Disability in Aging Adults.JAMA network open · 2026Article
- Urban Exposures, Frailty, and Mental Illness in World Trade Center Health Program Responders.medRxiv : the preprint server for health sciences · 2026Article
- When air gets heavy: joint PMFrontiers in public health · 2026Article
- Resources and applications of public biomedical data.Frontiers in bioinformatics · 2026Review
- Long-term exposure to ambient PMScientific reports · 2025Article
- [The older population in the context of air pollution and climate change : Current vulnerability and prevention of associated risks].Zeitschrift fur Gerontologie und Geriatrie · 2025Article
- Social isolation in relation to the incidence and dynamic progression of frailty in the oldest old: a trajectory analysis of a nationwide cohort.BMC public health · 2025Article
- The impact of ambient temperature on frailty progression in older adults: Evidence from a longitudinal study in China.Frontiers in public health · 2025Article
- The association between multimorbidity patterns and physical frailty among middle-aged and older community-dwelling adults: the mediating role of depressive symptoms.Frontiers in public health · 2025Article
- The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES.Frontiers in psychiatry · 2025Article
- Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study.Cardiovascular diabetology · 2024Article
- Social support and frailty progression in community-dwelling older adults.Frontiers in public health · 2024Article
- Article
- Is waist-calf circumference ratio associated with frailty in older adults? Findings from a cohort study.BMC geriatrics · 2023Article
- Causal association between air pollution and frailty: a Mendelian randomization study.Frontiers in public health · 2023Article
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between fine particular matter (PM2.5) and frailty is less studied, and the national burden of PM2.5-related frailty in China is unknown.
objectiveTo explore the association between PM2.5 exposure and incident frailty in older adults, and estimate the corresponding disease burden.
designChinese Longitudinal Healthy Longevity Survey from 1998 to 2014.
settingTwenty-three provinces in China. SUBJECTS: A total of 25,047 participants aged ≥65-year-old.
methodsCox proportional hazards models were performed to evaluate the association between PM2.5 and frailty in older adults. A method adapted from the Global Burden of Disease Study was used to calculate the PM2.5-related frailty disease burden.
resultsA total of 5,733 incidents of frailty were observed during 107,814.8 person-years follow-up. A 10 μg/m3 increment of PM2.5 was associated with a 5.0% increase in the risk of frailty (Hazard Ratio = 1.05, 95% confidence interval = [1.03-1.07]). Monotonic, but non-linear exposure-response, relationships of PM2.5 with risk of frailty were observed, and slopes were steeper at concentrations >50 μg/m³. Considering the interaction between population ageing and mitigation of PM2.5, the PM2.5-related frailty cases were almost unchanged in 2010, 2020 and 2030, with estimations of 664,097, 730,858 and 665,169, respectively.
conclusionsThis nation-wide prospective cohort study showed a positive association between long-term PM2.5 exposure and frailty incidence. The estimated disease burden indicated that implementing clean air actions may prevent frailty and substantially offset the burden of population ageing worldwide.
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