Evidence map›Paper›PMID 36794698›Full record

ArticleCancer medicine2023

Prognostic analysis of three forms of Ki-67 in patients with breast cancer with non-pathological complete response before and after neoadjuvant systemic treatment.

Weiwei Zhang, Yinggang Xu, Ye Wang, Jinzhi He, Rui Chen, Xinyu Wan, Wenjie Shi, Xiaofeng Huang, Xiaoqing Shi, Jue Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Weiwei ZhangDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yinggang XuDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ye WangDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jinzhi HeDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Rui ChenDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xinyu WanDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wenjie ShiDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0002-7564-3057
Xiaofeng HuangDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiaoqing ShiDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jue WangDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiaoming ZhaDepartment of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0001-5878-8433
Jiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients who do not achieve a pathological complete response (pCR) after neoadjuvant systemic treatment (NST) have a significantly worse prognosis. A reliable predictor of prognosis is required to further subdivide non-pCR patients. To date, the prognostic role in terms of disease-free survival (DFS) between the terminal index of Ki-67 after surgery (Ki-67

aimThis study aimed to explore the most useful form or combination of Ki-67 that can provide prognostic information to non-pCR patients. PATIENTS AND

methodsWe retrospectively reviewed 499 patients who were diagnosed with inoperable breast cancer between August 2013 and December 2020 and received NST with anthracycline plus taxane.

resultsAmong all the patients, 335 did not achieve pCR (with a follow-up period of ≥1 year). The median follow-up duration was 36 months. The optimal cutoff value of Ki-67

conclusionsKi-67

Indexed as

Breast NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsDisease-Free SurvivalFemaleHumansKi-67 AntigenNeoadjuvant TherapyPrognosisRetrospective StudiesKi-67 Antigenbreast cancercell cycleneoadjuvant chemotherapyprognosis

Identifiers

PMID36794698
PMCPMC10166904
OpenAlexW4321003580

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.