ReviewJournal of applied physiology (Bethesda, Md. : 1985)2023
Prolonged sitting and peripheral vascular function: potential mechanisms and methodological considerations.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Effects of Alternating Mild-Cold and Hot Water Immersion on Lower-Leg Blood Flow Following Immersion in Healthy Young Adults.Scandinavian journal of medicine & science in sports · 2026Trial
- Leg fidgeting alleviates reduced oxygen extraction in the gastrocnemius muscle caused by prolonged sitting: a randomized crossover trial.European journal of applied physiology · 2025Trial
- Acute effects of "exercise snacks" during prolonged sitting on hemodynamics and peripheral vascular function: a three-level meta-analysis.Nutrition & metabolism · 2026Article
- The effect of uninterrupted and interrupted sitting on vascular function in adults with long COVID.Physiological reports · 2025Article
- Leg-fidgeting versus standing breaks during prolonged sitting: Impacts on blood pressure and heart rate in young women.Experimental physiology · 2025Article
- Vascular Calcification Amplifies Limb Flexion-Induced Arterial Deformations and Causes Intermittent Vessel Pinching.Annals of surgery · 2025Article
- Prolonged sitting is not associated with altered shear-mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function.Physiological reports · 2025Article
- Metabolome Alterations Associated with Three-Month Sitting-Time Reduction Among Sedentary Postmenopausal Latinas with Cardiometabolic Disease Risk.Metabolites · 2025Article
- Joint exposure to PMFrontiers in public health · 2025Article
- Exercise snacks and physical fitness in sedentary populations.Sports medicine and health science · 2025Review
- Sitting Interruption Modalities during Prolonged Sitting Acutely Improve Postprandial Metabolome in a Crossover Pilot Trial among Postmenopausal Women.Metabolites · 2024Article
- A tree-based corpus annotated with Cyber-Syndrome, symptoms, and acupoints.Scientific data · 2024Article
- The effect of cardiorespiratory fitness and habitual physical activity on cardiovascular responses to 2 h of uninterrupted sitting.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Physiology of sedentary behavior.Physiological reviews · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Sitting time is associated with increased risks for subclinical atherosclerosis and cardiovascular disease development, and this is thought to be partially due to sitting-induced disturbances in macro- and microvascular function as well as molecular imbalances. Despite surmounting evidence supporting these claims, contributing mechanisms to these phenomena remain largely unknown. In this review, we discuss evidence for potential mechanisms of sitting-induced perturbations in peripheral hemodynamics and vascular function and how these potential mechanisms may be targeted using active and passive muscular contraction methods. Furthermore, we also highlight concerns regarding the experimental environment and population considerations for future studies. Optimizing prolonged sitting investigations may allow us to not only better understand the hypothesized sitting-induced transient proatherogenic environment but to also enhance methods and devise mechanistic targets to salvage sitting-induced attenuations in vascular function, which may ultimately play a role in averting atherosclerosis and cardiovascular disease development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.