ArticleAutism : the international journal of research and practice2023
Psychological, behavioural and biological factors associated with gastrointestinal symptoms in autistic adults and adults with autistic traits.
Article in Autism : the international journal of research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Potential gut-brain axis-targeted therapies for autism spectrum disorder in children: opportunities and challenges.World journal of pediatrics : WJP · 2025Pooled it
- The search for gastrointestinal inflammation in autism: a systematic review and meta-analysis of non-invasive gastrointestinal markers.Molecular autism · 2024Pooled it
- Clinical Characteristics and Blood-Based Inflammatory Indices of Psychiatric Hospitalizations Among Children with Autism in China: A Retrospective Electronic Medical Records Study.Brain sciences · 2026Article
- Association of adverse childhood experiences and gastrointestinal and liver diseases among middle-aged and elderly adults in China.Epidemiology and psychiatric sciences · 2026Article
- Hair Cortisol in Young Children with Autism and Their Parents: Associations with Child Mental Health, Eating Behavior and Weight Status.Journal of autism and developmental disorders · 2026Article
- The impact of the COVID-19 pandemic on the well-being of autistic and non-autistic adults in Eastern Germany.BMC psychiatry · 2025Article
- Age-Dependent Gut Microbiome Dysbiosis in Autism Spectrum Disorder and the Role of Key Bacterial Ratios.Nutrients · 2025Article
- Impact of Relaxation and Music Intervention on Psychological and Gastrointestinal Health in Military Recruits: A Prospective Study.Therapeutics and clinical risk management · 2025Article
- Pathways to Anxiety and Depression in Autistic Adolescents and Adults.Depression and anxiety · 2023Article
- Metabolic syndrome in adults with autistic traits: associated psychological, behavioral, and biological factors in females and males - a PharmLines initiative.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
lay abstractLittle is known about factors related to the increased risk for gastrointestinal symptoms in adults with an autism spectrum disorder (ASD), while the negative impact of gastrointestinal symptoms is evident. Especially, the relationship between gastrointestinal symptoms and psychological, behavioural, and biological risk factors in adults with ASD (traits) is unclear. Autistic peer support workers and autism-advocates also emphasised the importance of identifying risk factors, because of the high prevalence of gastrointestinal problems in people with ASD. Therefore, our study investigated which psychological, behavioural, and biological factors are associated with gastrointestinal symptoms in adults with ASD or with autistic traits. We analysed data from 31,185 adults in the Dutch Lifelines Study. Questionnaires were used to evaluate the presence of an autism spectrum disorder diagnosis, autistic traits, gastrointestinal symptoms, psychological and behavioural factors. Biological factors were examined with body measurements. We found that not only adults with ASD but also adults with higher levels of autistic traits were at increased risk for gastrointestinal symptoms. Adults with ASD who experienced psychological problems (psychiatric problems, worse perceived health, chronic stress) had a higher risk for gastrointestinal symptoms than adults with ASD without these psychological problems. Moreover, adults with higher levels of autistic traits were less physically active, which was also associated with gastrointestinal symptoms. In conclusion, our study highlights the relevance of identifying psychological problems and evaluating physical activity when trying to help adults with ASD or autistic traits and gastrointestinal symptoms. This suggests that healthcare professionals should be more aware of behavioural and psychological risk factors when evaluating gastrointestinal symptoms in adults with ASD (traits).
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