Evidence map›Paper›PMID 36794161›Full record

ArticleInternational journal of medical sciences2023

Klotho promotes AMPK activity and maintains renal vascular integrity by regulating the YAP signaling pathway.

Lei Luo, Jianming Guo, Yi Li, Te Liu, Lingyun Lai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The NDR family of kinases: essential regulators of aging.Frontiers in molecular neuroscience · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lei LuoThe Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Jianming GuoDepartment of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Yi LiThe Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Te LiuShanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China.
Lingyun LaiDivision of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Longhua Hospital Shanghai University of Traditional Chinese Medicine · CNCapital Medical University · CNHuashan Hospital · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and formation of mammalian blood vessels are closely related to the regulation of signal transduction pathways. Klotho/AMPK and YAP/TAZ signaling pathways are closely related to angiogenesis, but the internal relationship between them is not clear. In this study, we found that Klotho heterozygous deletion mice (Klotho

Indexed as

Adaptor Proteins, Signal TransducingAMP-Activated Protein KinasesKlotho ProteinsAnimalsCell Cycle ProteinsCell ProliferationEndothelial CellsMiceProtein Serine-Threonine KinasesSignal TransductionTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesCell Cycle ProteinsKlotho ProteinsKl protein, mouseProtein Serine-Threonine KinasesTranscription FactorsYAP-Signaling ProteinsAMPK/YAP pathwayKlothoVascular structure integrity

Identifiers

PMID36794161
PMCPMC9925983
OpenAlexW4318825020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.