ArticlePhotoacoustics2023
Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis.
Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Volumetric photoacoustic imaging of elastin and age-related remodeling using near-infrared probe ElaNIR.Photoacoustics · 2026Article
- Review
- Differentiation of sphingomyelin and cholesterol by hyperspectral mid-infrared detection of single-bond vibrational modes in the fingerprint region.Nature methods · 2026Article
- Mapping glucose-induced hemodynamics in white fat depots with label-free optoacoustics.Photoacoustics · 2026Article
- Multi-wavelength graph convolutional network for high-performance sparse multispectral optoacoustic tomography.Photoacoustics · 2025Article
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- Multimodal Diagnostic Imaging of Metabolic Dysfunction-Associated Steatotic Liver Disease: Noninvasive Analyses by Photoacoustic Ultrasound and Magnetic Resonance Imaging.The American journal of pathology · 2025Article
- Quantitative volumetric photoacoustic assessment of vasoconstriction by topical corticosteroid application in mice skin.Photoacoustics · 2024Article
- Near-infrared multispectral photoacoustic analysis of lipids and intraplaque hemorrhage in human carotid artery atherosclerosis.Photoacoustics · 2024Article
- Video-rate endocavity photoacoustic/harmonic ultrasound imaging with miniaturized light delivery.Journal of biomedical optics · 2024Article
- Clinical and Translational Imaging and Sensing of Diabetic Microangiopathy: A Narrative Review.Journal of cardiovascular development and disease · 2023Review
- A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption.Photoacoustics · 2023Review
- Functional photoacoustic imaging: from nano- and micro- to macro-scale.Nano convergence · 2023Review
- Skeletal muscle optoacoustics reveals patterns of circulatory function and oxygen metabolism during exercise.Photoacoustics · 2023Article
- Optoacoustic biomarkers of lipids, hemorrhage and inflammation in carotid atherosclerosis.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies.
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