ArticleFrontiers in behavioral neuroscience2022
Arc-driven mGRASP highlights CA1 to CA3 synaptic engrams.
Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Reactivation of memory-associated neurons induces downstream suppression of competing neuronal populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Astrocytes and Tinnitus.Brain sciences · 2024Review
- Fiber-basedNeurophotonics · 2024Article
- Visualizing traumatic stress-induced structural plasticity in a medial amygdala pathway using mGRASP.Frontiers in molecular neuroscience · 2023Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
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Abstract
Subpopulations of neurons display increased activity during memory encoding and manipulating the activity of these neurons can induce artificial formation or erasure of memories. Thus, these neurons are thought to be cellular engrams. Moreover, correlated activity between pre- and postsynaptic engram neurons is thought to lead to strengthening of their synaptic connections, thus increasing the probability of neural activity patterns occurring during encoding to reoccur at recall. Therefore, synapses between engram neurons can also be considered as a substrate of memory, or a synaptic engram. One can label synaptic engrams by targeting two complementary, non-fluorescent, synapse-targeted GFP fragments separately to the pre- and postsynaptic compartment of engram neurons; the two GFP fragments reconstitute a fluorescent GFP at the synaptic cleft between the engram neurons, thereby highlighting synaptic engrams. In this work we explored a transsynaptic GFP reconstitution system (mGRASP) to label synaptic engrams between hippocampal CA1 and CA3 engram neurons identified by different Immediate-Early Genes:
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