Evidence map›Paper›PMID 36793786›Full record

ArticleFrontiers in molecular biosciences2023

Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse.

Margaret J Fuller, Subhash C Gupta, Rong Fan, Rebecca J Taugher-Hebl, Grace Z Wang, Noah R R Andrys, Amal K Bera, Jason J Radley, John A Wemmie

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Margaret J FullerDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Subhash C GuptaDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Rong FanDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Rebecca J Taugher-HeblDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Grace Z WangDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Noah R R AndrysDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
Amal K BeraDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Jason J RadleyDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, United States.
John A WemmieDepartment of Psychiatry, University of Iowa, Iowa City, IA, United States.
University of Iowa · USIndian Institute of Technology Madras · IN

Funding

The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)T32MH019113 · NIMH · UNIVERSITY OF IOWA · PI HANNA E STEVENS, John A Wemmie · 1991 to 2026
$5.6M
Novel mechanisms for correcting opioid-induced synaptic abnormalitiesR01DA052953 · NIDA · UNIVERSITY OF IOWA · PI WEMMIE, JOHN A · 2021 to 2025
$2.3M
Modulation of Synaptic and Behavioral Measures of Addiction by Acid-sensing Ion ChannelsR01DA037216 · NIDA · UNIVERSITY OF IOWA · PI LALUMIERE, RYAN T, WEMMIE, JOHN A · 2014 to 2018
$1.8M
Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behaviorI01BX004440 · VA · IOWA CITY VA MEDICAL CENTER · PI John A Wemmie · 2020 to 2026
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BLRD VA I01 BX004440NIDA NIH HHS R01 DA037216NIDA NIH HHS R01 DA052953NIMH NIH HHS T32 MH019113
6 · The paper itself

Abstract

Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A subunit. However, the ASIC2A and ASIC2B subunits are known to interact with ASIC1A, and their potential roles in drugs of abuse have not yet been investigated. Therefore, we tested the effects of disrupting ASIC2 subunits in mice exposed to drugs of abuse. We found conditioned place preference (CPP) to both cocaine and morphine were increased in

Indexed as

acid-sensing ion channel (ASIC)ASICASIC2cocainedendritic spinesmorphinenucleus accumbensopioid

Identifiers

PMID36793786
PMCPMC9923001
OpenAlexW4318465570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.