Evidence map›Paper›PMID 36793731›Full record

ArticleFrontiers in immunology2023

SRA inhibition improves antitumor potency of antigen-targeted chaperone vaccine.

Jie Qian, Xiaofei Yu, Zheng Liu, Jinyang Cai, Masoud H Manjili, Hu Yang, Chunqing Guo, Xiang-Yang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jie QianDepartment of Human & Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Xiaofei YuDepartment of Human & Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Zheng LiuDepartment of Human & Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Jinyang CaiDepartment of Human & Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Masoud H ManjiliDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Hu YangLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, United States.
Chunqing GuoDepartment of Human & Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Xiang-Yang WangDepartment of Human & Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Virginia Commonwealth University · USMissouri University of Science and Technology · US

Funding

Large Stress Proteins in Biology and MedicineR01CA154708 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI WANG, XIANG-YANG SHAWN · 2011 to 2015
$1.5M
Scavenger Receptor-A and Immune RegulationR01CA129111 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI WANG, XIANG-YANG SHAWN · 2007 to 2011
$1.2M
NCI NIH HHS R01 CA129111NCI NIH HHS R01 CA154708
6 · The paper itself

Abstract

We have previously demonstrated that scavenger receptor A (SRA) acts as an immunosuppressive regulator of dendritic cell (DC) function in activating antitumor T cells. Here we investigate the potential of inhibiting SRA activity to enhance DC-targeted chaperone vaccines including one that was recently evaluated in melanoma patients. We show that short hairpin RNA-mediated SRA silencing significantly enhances the immunogenicity of DCs that have captured chaperone vaccines designed to target melanoma (i.e., hsp110-gp100) and breast cancer (i.e., hsp110-HER/Neu-ICD). SRA downregulation results in heightened activation of antigen-specific T cells and increased CD8

Indexed as

Cancer VaccinesChitosanMelanoma, ExperimentalAnimalsAntigensDendritic CellsInterferon-gammaInterleukin-12MiceMolecular ChaperonesReceptors, ScavengerRNA, Small InterferingAntigensCancer VaccinesChitosanInterferon-gammaInterleukin-12Molecular ChaperonesReceptors, ScavengerRNA, Small Interferingdendritic cellheat shock protein 110immunotherapyscavenger receptor A (SRA)vaccine

Identifiers

PMID36793731
PMCPMC9923017
OpenAlexW4318473681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.