ArticleWorld journal of clinical cases2023
Successful treatment of patients with refractory idiopathic membranous nephropathy with low-dose Rituximab: A single-center experience.
Article in World journal of clinical cases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Obinutuzumab: a new frontier in the treatment of refractory idiopathic membranous nephropathy.International urology and nephrology · 2025Article
- Anti-PLA2R antibody reduction as a predictor of treatment response in primary membranous nephropathy: a retrospective study.Jornal brasileiro de nefrologiaArticle
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4 authors at 1 institution in 1 country.
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Abstract
backgroundThe recognition of idiopathic membranous nephropathy (IMN) as an autoimmune disease has paved the way for the use of B-cell-depleting agents, such as Rituximab (RTX), which is now a first-line drug for treating IMN with proven safety and efficacy. Nevertheless, the usage of RTX for the treatment of refractory IMN remains controversial and challenging.
aimTo evaluate the efficacy and safety of a new low-dose RTX regimen for the treatment of patients with refractory IMN.
methodsA retrospective study was performed on refractory IMN patients that accepted a low-dose RTX regimen (RTX, 200 mg, once a month for five months) in the Xiyuan Hospital of Chinese Academy of Chinese Medical Sciences' Department of Nephrology from October 2019 to December 2021. To assess the clinical and immune remission data, we performed a 24 h urinary protein quantification (UTP) test and measured the serum albumin (ALB) and serum creatinine (SCr) levels, phospholipase A2 receptor (PLA2R) antibody titer, and CD19
resultsA total of nine refractory IMN patients were analyzed. During follow-up conducted twelve months later, the results from the 24 h UTP decreased from baseline [8.14 ± 6.05 g/d to 1.24 ± 1.34 g/d (
conclusionOur low-dose RTX regimen appears to be a promising treatment strategy for refractory IMN.
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