Evidence map›Paper›PMID 36793610›Full record

SynthesisFrontiers in oncology2023

Unicentric form of Castleman´s disease, pitfalls of diagnosis and surgical treatment.

Jiri Molacek, Vladislav Treska, Tomas Skalicky, Josef Vodicka, Jiri Ferda, Eva Ferdova, Jan Baxa, Christiana Mach, Alexandra Jungova, Michael Michal

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Intrapulmonary unicentric Castleman's Disease: A clinical analysis of 8 patients.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2026
    Article
  3. Breast-implant associated unicentric castleman disease: a case report.Current problems in cancer. Case reports · 2026
    Article
  4. Snapshot Look at Castleman Disease.Journal of cellular and molecular medicine · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jiri MolacekFaculty of Medicine in Pilsen, Charles University, Plzen, Czechia.
Vladislav TreskaDepartment of Surgery, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Tomas SkalickyDepartment of Surgery, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Josef VodickaDepartment of Surgery, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Jiri FerdaDepartment of Imaging Methods, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Eva FerdovaDepartment of Imaging Methods, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Jan BaxaDepartment of Imaging Methods, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Christiana MachDepartment of Surgery, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Alexandra JungovaDepartment of Hematology and Oncology, University Hospital in Pilsen, Plzen, Czechia.
Michael MichalFaculty of Medicine in Pilsen, Charles University, Plzen, Czechia.
Charles University · CZUniversity Hospital Plzen · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Castleman´s disease is an extremely rare heterogenous lymphoproliferative pathology with a mostly benign behavior. It is a localized or generalized lymph node enlargement of an unknown aetiology. Unicentric form is typically a slow-growing solitary mass occurring mostly in the mediastinum, abdominal cavity, retroperitoneum, pelvis and neck. Aetiology and pathogenesis of CD is probably diverse, varying in different types of this heterogeneous disease. Materials and Methods: Authors present a review of this issue based on their extensive experience. The aim is to summarize the crucial factors in the management of diagnostics and a surgical treatment of the unicentric form of Castleman´s disease. One of the key issues in the unicentric form is precise preoperative diagnostics and thus choosing the right surgical treatment strategy. Authors highlight pitfalls of the diagnosis and surgical treatment. Results: All histological types such as a hyaline vascular type, plasmacytic type and a mixed type are presented as well as options of surgical and conservative treatment. Differential diagnosis and malignant potential is discussed. Conclusion: Patients with Castleman´s disease should be treated in the high- volume centers, with a great experience in major surgical procedures as well as with preoperative imaging diagnostic techniques. Specialized pathologists and oncologists focusing on this issue are also absolutely necessary to avoid misdiagnosis. Only this complex approach can lead to excellent outcomes in patients with UCD.

Indexed as

Castleman diseasediagnosispitfallssurgical treatmentunicentric Castleman

Identifiers

PMID36793610
PMCPMC9923952
OpenAlexW4318481071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.