Evidence map›Paper›PMID 36793268›Full record

ArticleJournal of current glaucoma practice

Bleb-related Porcine Lymphatic Outflow is Greater from Subconjunctival compared to Subtenon Blebs.

Jong Yeon Lee, Clemens Adolf Strohmaier, Goichi Akiyama, Sindhu Saraswathy, Chungkwon Yoo, Yong Yeon Kim, Young-Kwon Hong, Alex S Huang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of current glaucoma practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jong Yeon LeeDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA; Department of Ophthalmology, Gachon University College of Medicine, Gil Medical Center, Incheon, Korea.
Clemens Adolf StrohmaierDepartment of Ophthalmology, Johannes Kepler University, Linz, Austria; The Viterbi Family Department of Ophthalmology, Shiley Eye Institute, Hamilton Glaucoma Center, University of California, San Diego, California.ORCID https://orcid.org/0000-0001-8249-1138
Goichi AkiyamaJikei School of Medicine, Tokyo, Japan.
Sindhu SaraswathyDoheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Chungkwon YooDepartment of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Yong Yeon KimDepartment of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Young-Kwon HongDepartment of Surgery, Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alex S HuangAlfred Vogt Endowed Chair in Ophthalmology, The Viterbi Family Department of Ophthalmology, Shiley Eye Institute, Hamilton Glaucoma Center, University of California, San Diego, California, USA.
Korea University · KRJikei University School of Medicine · JPUniversity of California, Los Angeles · US

Funding

Dynamic Variable Aqueous Humor Outflow and Glaucoma Therapies in the Human EyeR01EY030501 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Alex Huang, Hao F Zhang · 2020 to 2026
$3.5M
Flow Dependent Development and Maintenance of Schlemm's CanalR21EY026260 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HONG, YOUNG-KWON · 2016 to 2017
$454k
NEI NIH HHS R01 EY030501NEI NIH HHS R21 EY026260
6 · The paper itself

Abstract

Aim: Understanding the mechanism of fluid outflow by comparing the subconjunctival and subtenon spaces can lead to improved ocular therapeutics. The purpose of the current study is to evaluate subconjunctival vs subtenon lymphatic outflow by creating tracer-filled blebs in each location. Methods: Porcine ( Results: Subconjunctival blebs demonstrated a greater number of lymphatic outflow pathways compared to subtenon blebs in every quadrant [superior: 6.10 ± 1.18 (subconjunctival) vs 0.50 ± 0.27 (subtenon); temporal: 2.30 ± 0.40 vs 0.10 ± 0.10; nasal: 5.30 ± 0.60 vs 0.30 ± 0.21; inferior: 6.00 ±1.29 vs 0.1 ± 0.1; all comparisons Discussion: Subconjunctival blebs accessed greater lymphatic outflow compared to subtenon blebs. Furthermore, regional differences existed, with fewer lymphatic vessels temporal than at the other locations. Clinical significance: Aqueous humor drainage after glaucoma surgery is incompletely understood. The present manuscript adds to our understanding of how lymphatics might influence filtration bleb function. How to cite this article: Lee JY, Strohmaier CA, Akiyama G,

Indexed as

Aqueous outflowBlebsConjunctivaGlaucoma surgeryLaboratory researchLymphaticsSubconjunctivalSubtenon

Identifiers

PMID36793268
PMCPMC9905879
OpenAlexW4317830828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.