Evidence map›Paper›PMID 36793184›Full record

ArticleBrain and behavior2023

Characterization of visual processing in temporomandibular disorders using functional magnetic resonance imaging.

Daniel E Harper, Kaundinya Gopinath, Jeremy L Smith, Mia Gregory, Eric Ichesco, Sharon Aronovich, Richard E Harris, Steven E Harte, Daniel J Clauw, Candace C Fleischer

Open access · goldFull text read
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Daniel E HarperDepartment of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-7373-940X
Kaundinya GopinathDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Jeremy L SmithDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-0841-5297
Mia GregorySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA.
Eric IchescoChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Sharon AronovichDepartment of Oral and Maxillofacial Surgery and Hospital Dentistry, University of Michigan, Michigan Medicine, Ann Arbor, Michigan, USA.ORCID 0000-0002-5201-4952
Richard E HarrisChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Steven E HarteChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Daniel J ClauwChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Candace C FleischerDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-3265-2276
University of Michigan · USEmory University · USGeorgia Institute of Technology · US

Funding

Mechanistic Characterization of Pain in Temporomandibular Disorders: Does Pain Centralization Influence Responsiveness to Peripherally Targeted Treatments?K99DE026810 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARPER, DANIEL ELLIOTT · 2017 to 2018
$236k
NIH HHS K99DE026810
6 · The paper itself

Abstract

background and purposeMany patients with chronic pain report hypersensitivity not only to noxious stimuli, but also to other modalities including innocuous touch, sound, and light, possibly due to differences in the processing of these stimuli. The goal of this study was to characterize functional connectivity (FC) differences between subjects with temporomandibular disorders (TMD) and pain-free controls during a visual functional magnetic resonance imaging (fMRI) task that included an unpleasant, strobing visual stimulus. We hypothesized the TMD cohort would exhibit maladaptations in brain networks consistent with multisensory hypersensitivities observed in TMD patients.

methodsThis pilot study included 16 subjects, 10 with TMD and 6 pain-free controls. Clinical pain was characterized using self-reported questionnaires. Visual task-based fMRI data were collected on a 3T MR scanner and used to determine differences in FC via group independent component analysis.

resultsCompared to controls, subjects with TMD exhibited abnormally increased FC between the default mode network and lateral prefrontal areas involved in attention and executive function, and impaired FC between the frontoparietal network and higher order visual processing areas.

conclusionsThe results indicate maladaptation of brain functional networks, likely due to deficits in multisensory integration, default mode network function, and visual attention and engendered by chronic pain mechanisms.

Indexed as

Chronic PainTemporomandibular Joint DisordersBrainBrain MappingHumansMagnetic Resonance ImagingPilot ProjectsVisual Perceptionchronic painfMRIMRITMDvisual processing

Identifiers

PMID36793184
PMCPMC10013945
OpenAlexW4321004382

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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measurements read1
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.