Evidence map›Paper›PMID 36793141›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

X-Ray Activatable Au/Ag Nanorods for Tumor Radioimmunotherapy Sensitization and Monitoring of the Therapeutic Response Using NIR-II Photoacoustic Imaging.

Si Zheng, Duyang Gao, Yayun Wu, Dehong Hu, Ziyue Li, Yuenan Wang, Hairong Zheng, Yingjia Li, Zonghai Sheng

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Assembling AuJournal of nanobiotechnology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Si ZhengDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.
Duyang GaoPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.ORCID 0000-0003-0605-4678
Yayun WuPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.ORCID 0000-0002-5735-8156
Dehong HuPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
Ziyue LiDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.
Yuenan WangDepartment of Radiation Oncology, Peking University Shenzhen Hospital, Shenzhen, 518036, P. R. China.
Hairong ZhengPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
Yingjia LiDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.ORCID 0000-0002-8885-2317
Zonghai ShengPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.ORCID 0000-0003-0289-029X
Chinese Academy of Sciences · CNNanfang Hospital · CNPeking University Shenzhen Hospital · CN

Funding

Clinical Research Grant of Peking University Shenzhen Hospital LCYJ2021018Guangdong Basic and Applied Basic Research Fund 2022A1515010384Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province 2020B1212060051Key Technology and Equipment R&D Program of Major Science and Technology Infrastructure of Shenzhen 202100102Key Technology and Equipment R&D Program of Major Science and Technology Infrastructure of Shenzhen 202100104Natural Science Foundation of China 22204170Natural Science Foundation of China 81871371Natural Science Foundation of China 81901812Natural Science Foundation of China 81927807Natural Science Foundation of China 82027803Natural Science Foundation of China 82071949Natural Science Foundation of China 82171958Natural Science Foundation of China 82271998Natural Science Foundation of China 92159304Science and Technology Key Project of Shenzhen JCYJ20190812163614809Science and Technology Key Project of Shenzhen JCYJ20200109114612308Science and Technology Key Project of Shenzhen JCYJ20210324110210029Science and Technology Key Project of Shenzhen JCYJ20210324120011030
6 · The paper itself

Abstract

Radioimmunotherapy (RIT) is an advanced physical therapy used to kill primary cancer cells and inhibit the growth of distant metastatic cancer cells. However, challenges remain because RIT generally has low efficacy and serious side effects, and its effects are difficult to monitor in vivo. This work reports that Au/Ag nanorods (NRs) enhance the effectiveness of RIT against cancer while allowing the therapeutic response to be monitored using activatable photoacoustic (PA) imaging in the second near-infrared region (NIR-II, 1000-1700 nm). The Au/Ag NRs can be etched using high-energy X-ray to release silver ions (Ag

Indexed as

NanotubesNeoplasmsPhotoacoustic TechniquesAnimalsMiceRadioimmunotherapyX-Raysactivatable imagingAu/Ag nanorodsphotoacoustic imagingradioimmunotherapysecond near-infrared region

Identifiers

PMID36793141
PMCPMC10104665
OpenAlexW4321003461

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.