Evidence map›Paper›PMID 36792840›Full record

SynthesisBiochemical genetics2023

Genetic Association of LEP Gene Polymorphisms with Obesity in Moroccan Individuals: Case-Control Study and Updated Meta-analysis.

Hind Bouafi, Al Mehdi Krami, Imane Morjane, Kenza Slaoui, Houda Harmak, Hicham Charoute, Rachid Saile, Abdelhamid Barakat

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Biochemical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hind BouafiBiology and Health Laboratory, Health and Biotechnology Research Center, Ben M'Sik Faculty of Sciences, Hassan II University of Casablanca, Casablanca, Morocco.
Al Mehdi KramiHuman Genomics and Genetics Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Imane MorjaneHuman Genomics and Genetics Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Kenza SlaouiHuman Genomics and Genetics Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Houda HarmakHuman Genomics and Genetics Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Hicham CharouteResearch Unit of Epidemiology, Biostatistics and Bioinformatics, Institut Pasteur du Maroc, Casablanca, Morocco.
Rachid SaileBiology and Health Laboratory, Health and Biotechnology Research Center, Ben M'Sik Faculty of Sciences, Hassan II University of Casablanca, Casablanca, Morocco.
Abdelhamid BarakatHuman Genomics and Genetics Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco. hamid.barakat@pasteur.ma.
Institut Pasteur du Maroc · MAUniversity of Hassan II Casablanca · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a global epidemic disease representing the fifth leading cause of death in the world. It was shown that it is caused by the interaction between environmental factors and genes including leptin gene (LEP). This paper aimed to analyze the association between the LEP gene polymorphisms rs7799039 and rs11761556 with obesity in Moroccan individuals as well as to perform an update meta-analysis of this genetic association. Both polymorphisms were genotyped in 146 obesity patients and 104 controls using real-time PCR technique. The genetic association analysis and the comparison of quantitative parameters were carried out using the R language. Moreover, a meta-analysis including 20 genetic association studies was performed using Review Manager 5.3 software. No significant association was found between the polymorphisms rs7799039 and rs11761556 and the risk of obesity. The comparison of biochemical and clinical parameters between the genotypes of the rs7799039 polymorphism, showed a significant increased triglycerides levels in carriers of AA or GA genotypes (P value = 0.040). The meta-analysis showed no significant association between the rs7799039 polymorphism and obesity under all genetic models. In conclusion, the case-control study and meta-analysis demonstrated that the LEP gene polymorphisms rs7799039 and rs11761556 cannot be considered as genetic risk factors for obesity.

Indexed as

LeptinPolymorphism, Single NucleotideCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansObesityReceptors, LeptinLeptinReceptors, LeptinGenetic associationLEP geneMeta-analysisObesityPolymorphism

Identifiers

PMID36792840
OpenAlexW4320896683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.