ArticleNature2023
A NPAS4-NuA4 complex couples synaptic activity to DNA repair.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
18.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- The romantic history of signaling pathway discovery in cell death: an updated review.Molecular and cellular biochemistry · 2024Pooled it
- cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy.Nature neuroscience · 2026Article
- Neuronal activity-driven 3D chromatin dynamics in cortical pyramidal neurons depend on SATB2.Nucleic acids research · 2026Article
- Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life.The EMBO journal · 2026Article
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- TIP60 acts as a wound-induced factor essential for efficient regeneration in planaria.The Journal of biological chemistry · 2026Article
- Disruption of DNA Repair as an Emerging Epigenetic Mechanism Underlying Autism Spectrum Disorder.Current psychiatry reports · 2026Review
- Site-specific DNA double-strand break induces local transcription in cis and protein expression.Communications biology · 2026Article
- Article
- AnnQ: reference-based quantification of cellular abnormality at single-cell resolution.Briefings in bioinformatics · 2026Article
- Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex.Nature neuroscience · 2026Article
- Fn14 is an activity-dependent, Bmal1-regulated cytokine receptor that induces rod-like microglia and restricts neuronal activity in vivo.Cell reports · 2026Article
- A novel spliceosomopathy caused by de novo SF3B3 variants.Genome medicine · 2026Article
- Deciphering epileptogenic and activity-dependent gene programs in the human brain.bioRxiv : the preprint server for biology · 2026Article
- The Roles of Topoisomerases in Transcriptional Regulation.International journal of molecular sciences · 2026Review
- cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Review
- EpiBrain: the brain's epigenetic landscape in a snapshot.bioRxiv : the preprint server for biology · 2026Article
- Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside.Translational stroke research · 2026Review
- Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
16 authors at 2 institutions in 1 country.
Elizabeth A Pollina *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Daniel T Gilliam *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Andrew T LandauDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Cindy LinDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Naomi PajarilloDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Christopher P DavisDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
David A HarminDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Ee-Lynn YapDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Ian R VogelDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Eric C GriffithDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0428-3215
M Aurel NagyDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Emi LingDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5287-0284
Erin E DuffyDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7519-5098
Bernardo L SabatiniDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0095-9177
Charles J WeitzDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Michael E GreenbergDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. meg@hms.harvard.edu.ORCID http://orcid.org/0000-0003-1380-2160
Harvard University · USHoward Hughes Medical Institute · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MSupplement request for Training GrantT32NS007473 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI Elizabeth C. Engle, Thomas L. Schwarz · 1999 to 2026
$6.9MELECTRICAL STIMULATION OF IMMEDIATE GENESR01NS028829 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GREENBERG, MICHAEL ELDON · 1990 to 2024
$6.2MSuper-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8MAction and interaction of ionotropic and metabotropic neurotransmissionR37NS046579 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2018 to 2024
$4.6MNeuronal Circuit Maintenance in Healthy AgingK99AG064042 · NIA · HARVARD MEDICAL SCHOOL · PI POLLINA, ELIZABETH A · 2020 to 2022
$314kSpecification of Neuronal Enhancers during Postnatal DevelopmentF32NS112455 · NINDS · HARVARD MEDICAL SCHOOL · PI DAVIS, CHRISTOPHER PATRICK · 2019 to 2021
$149kNIA NIH HHS K99 AG064042NICHD NIH HHS P50 HD105351NIGMS NIH HHS T32 GM007753NINDS NIH HHS F32 NS112455NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS028829NINDS NIH HHS R37 NS046579NINDS NIH HHS T32 NS007473
Abstract
Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the stability of the genome across the long lifespan of postmitotic neurons
Indexed as
BrainDNA RepairMultiprotein ComplexesNeuronsSynapsesAgingBasic Helix-Loop-Helix ProteinsDNA Breaks, Double-StrandedGene Expression RegulationGenomeLongevityLysine Acetyltransferase 5MutationNeurodegenerative DiseasesBasic Helix-Loop-Helix ProteinsLysine Acetyltransferase 5Multiprotein Complexes
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.