ArticleGeroScience2023
Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter.
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Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 36 citations in OpenAlex.
- Contributions of previous whole-brain radiation therapy, cumulative intracranial tumor volume, and repeat radiosurgery to adverse radiation effects following stereotactic radiosurgery for brain metastasis.Clinical & experimental metastasis · 2026Article
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- Cortical OProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Diurnal differences in cerebral microvascular blood flow and oxygen delivery across brain regions in awake mice.Neurophotonics · 2026Article
- A Minimally Invasive Framework Reveals Region-Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS-ULM).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation-A Narrative Review.Nutrients · 2025Review
- Niacin Modulates SIRT1-Driven Signaling to Counteract Radiation-Induced Neurocognitive and Behavioral Impairments.International journal of molecular sciences · 2025Article
- Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.Theranostics · 2025Review
- Radiation-Induced Macrovessel/Microvessel Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis.Neuro-oncology · 2024Article
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- Cranial irradiation disrupts homeostatic microglial dynamic behavior.Journal of neuroinflammation · 2024Article
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- Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice.GeroScience · 2024Article
- Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype.Microcirculation (New York, N.Y. : 1994) · 2024Article
- The impact of XPC gene single nucleotide polymorphism rs2228001 on head and neck cancer patients' response to radiotherapy treatment.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024Article
- Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model.Frontiers in physiology · 2024Article
- Current dilemma and future directions over prophylactic cranial irradiation in SCLC: a systematic review in MRI and immunotherapy era.Frontiers in oncology · 2024Review
- The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.Nutrients · 2023Review
- Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain.GeroScience · 2023Article
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Authors and funding
17 authors at 6 institutions in 3 countries.
Baoqiang Li *Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China.ORCID 0000-0003-2992-3303
Andriy Yabluchanskiy *Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Stefano TarantiniVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Srinivasa Rao AlluDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ikbal Şencan-EğilmezAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Ji LengBrain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China.
Mohammed Ali H AlfadhelAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Jason E PorterAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Buyin FuAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Chongzhao RanAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Sefik Evren ErdenerDepartment of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
David A BoasDepartment of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Sergei A VinogradovDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
William E SonntagVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Anna CsiszarVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Zoltan UngvariVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. Zoltan-Ungvari@ouhsc.edu.
Sava SakadžićAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA. sava.sakadzic@mgh.harvard.edu.
Harvard University · USSemmelweis University · HUBoston University · USUniversity of Oklahoma Health Sciences Center · USUniversity of Pennsylvania · USChinese Academy of Sciences · CN
Funding
Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI David W Dyer · 2012 to 2026
$60.2MVisualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Veronica Galvan, William Edmund Sonntag · 2019 to 2026
$17.8MTargeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI William Edmund Sonntag · 2015 to 2026
$13.9MProject 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2021 to 2025
$13.4MGEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6MInvestigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical ImagingR01NS115401 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK, SAKADZIC, SAVA · 2020 to 2024
$3.5MTwo-Photon Microscopy of Oxygen Consumption in the BrainR01NS091230 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA · 2015 to 2019
$2.4MCerebral microhemorrhages and gait dysfunction in agingR01AG055395 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2017 to 2025
$2.3MMultiscale modeling of cerebral blood flow and oxygen transportU01HL133362 · NHLBI · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 2017 to 2021
$2.0MTwo-photon Imaging of Oxygen and Blood Flow in Retinal and Cerebral VasculatureRF1NS121095 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA, SHAHIDI, MAHNAZ · 2021 to 2021
$1.9MAge-related vascular cognitive impairment: role of endothelial senescenceR01AG068295 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA, UNGVARI, ZOLTAN ISTVAN · 2020 to 2024
$1.8MThe role of IGF-1 signaling in vascular smooth muscle cells in age-related vascular cognitive impairment and dementiaR01AG070915 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CONLEY, SHANNON M · 2021 to 2025
$1.8MBLRD VA I01 BX005592NCI NIH HHS R01 CA255840NHLBI NIH HHS U01 HL133362NIA NIH HHS K01 AG073614NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG055395NIA NIH HHS R01 AG068295NIA NIH HHS R01 AG070915NIA NIH HHS RF1 AG072295NIA NIH HHS T32 AG052363NIBIB NIH HHS U24 EB028941NIGMS NIH HHS P20 GM103447NIGMS NIH HHS P20 GM125528NIMH NIH HHS R00 MH120053NINDS NIH HHS R01 NS091230NINDS NIH HHS R01 NS100782NINDS NIH HHS R01 NS115401NINDS NIH HHS RF1 NS121095NINDS NIH HHS U19 NS123717
Abstract
Whole-brain irradiation (WBI, also known as whole-brain radiation therapy) is a mainstay treatment modality for patients with multiple brain metastases. It is also used as a prophylactic treatment for microscopic tumors that cannot be detected by magnetic resonance imaging. WBI induces a progressive cognitive decline in ~ 50% of the patients surviving over 6 months, significantly compromising the quality of life. There is increasing preclinical evidence that radiation-induced injury to the cerebral microvasculature and accelerated neurovascular senescence plays a central role in this side effect of WBI. To better understand this side effect, male C57BL/6 mice were first subjected to a clinically relevant protocol of fractionated WBI (5 Gy, two doses per week, for 4 weeks). Nine months post the WBI treatment, we applied two-photon microscopy and Doppler optical coherence tomography to measure capillary red-blood-cell (RBC) flux, capillary morphology, and microvascular oxygen partial pressure (PO
Indexed as
Brain NeoplasmsCognitive DysfunctionWhite MatterAnimalsBrainCerebrovascular CirculationCranial IrradiationDisease Models, AnimalMaleMiceMice, Inbred C57BLMicrocirculationMicroscopyOxygenQuality of LifeTomography, Optical CoherenceOxygenMicrovascular blood flowOptical microscopyVascular cognitive impairmentWhite matterWhole-brain radiation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.