ArticleAnalytical and bioanalytical chemistry2023
Determination of lysophosphatidylcholine using peroxidase-mimic PVP/PtRu nanozyme.
Article in Analytical and bioanalytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Development and Diagnostic Validation of an Automated Rapid Testing Platform for Serum Lysophosphatidylcholine as a Sepsis Biomarker.Annals of laboratory medicine · 2026Article
- Removing Barriers to Tumor 'Oxygenation': Depleting Glutathione Nanozymes in Cancer Therapy.International journal of nanomedicine · 2025Review
- Prediction and analysis of the tumor invasiveness of pulmonary ground-glass nodules based on metabolomics.Clinical and experimental medicine · 2024Article
- Rational design of cuprofullerene bipyridine nanozyme with high peroxidase-like activity for colorimetric sensing of bleomycin.Analytical and bioanalytical chemistry · 2024Article
- The mechanism of intrinsic peroxidase (POD)-like activity of attapulgite.Analytical and bioanalytical chemistry · 2024Article
- Recent Development and Application of "Nanozyme" Artificial Enzymes-A Review.Biomimetics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysophosphatidylcholine (LPC) can be used as a biomarker for diseases such as cancer, diabetes, atherosclerosis, and sepsis. In this study, we demonstrated the ability of nanozymes to displace the natural derived enzyme in enzyme-based assays for the measurement of LPC. Synthesized polyvinylpyrrolidone-stabilized platinum-ruthenium nanozymes (PVP/PtRu NZs) had a uniform size of 2.48 ± 0.24 nm and superb peroxidase-mimicking activity. We demonstrated that the nanozymes had high activity over a wide pH and temperature range and high stability after long-term storage. The LPC concentration could be accurately analyzed through the absorbance and fluorescence signals generated by the peroxidation reaction using the synthesized nanozyme with substrates such as 3,3',5,5'-tetramethylbenzidine (TMB) and 10-acetyl-3,7-dihydroxyphenoxazine (Ampliflu™ Red). LPC at a concentration of 0-400 µM was used for the analysis, and the coefficient of determination (R
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