Evidence map›Paper›PMID 36792768›Full record

ArticleAnnals of surgical oncology2023

Validation of a Resectability Scoring System for Prediction of Pancreatic Adenocarcinoma Surgical Outcomes.

Diego A S Toesca, Matthew Susko, Rie von Eyben, J Richelsyn M Baclay, Erqi L Pollom, R Brooke Jeffrey, Peter D Poullos, George A Poultsides, George A Fisher, Brendan C Visser and 3 more

Abstract read
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Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Diego A S ToescaDepartment of Radiation Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
Matthew SuskoDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.
Rie von EybenDepartment of Radiation Oncology, Stanford Cancer Institute, 875 Blake Wilbur Drive MC5847, Stanford, CA, 94305, USA.
J Richelsyn M BaclayDepartment of Radiation Oncology, Stanford Cancer Institute, 875 Blake Wilbur Drive MC5847, Stanford, CA, 94305, USA.
Erqi L PollomDepartment of Radiation Oncology, Stanford Cancer Institute, 875 Blake Wilbur Drive MC5847, Stanford, CA, 94305, USA.
R Brooke JeffreyDepartment of Radiology, Stanford Cancer Institute, Stanford, CA, USA.
Peter D PoullosDepartment of Radiology, Stanford Cancer Institute, Stanford, CA, USA.
George A PoultsidesDepartment of Surgery, Stanford Cancer Institute, Stanford, CA, USA.
George A FisherDepartment of Medical Oncology, Stanford Cancer Institute, Stanford, CA, USA.
Brendan C VisserDepartment of Surgery, Stanford Cancer Institute, Stanford, CA, USA.
Albert C KoongDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mary FengDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.
Daniel T ChangDepartment of Radiation Oncology, Stanford Cancer Institute, 875 Blake Wilbur Drive MC5847, Stanford, CA, 94305, USA. dtchangd@med.umich.edu.
Stanford Cancer InstituteUniversity of California, San Francisco · USMayo Clinic in Florida · USThe University of Texas MD Anderson Cancer Center · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe most used pancreatic cancer (PC) resectability criteria are descriptive in nature or based solely on dichotomous degree of involvement (< 180° or > 180°) of vessels, which allows for a high degree of subjectivity and inconsistency.

methodsRadiographic measurements of the circumferential degree and length of tumor contact with major peripancreatic vessels were retrospectively obtained from pre-treatment multi-detector computed tomography (MDCT) images from PC patients treated between 2001 and 2015 at two large academic institutions. Arterial and venous scores were calculated for each patient, then tested for a correlation with tumor resection and R0 resection.

resultsThe analysis included 466 patients. Arterial and venous scores were highly predictive of resection and R0 resection in both the training (n = 294) and validation (n = 172) cohorts. A recursive partitioning tree based on arterial and venous score cutoffs developed with the training cohort was able to stratify patients of the validation cohort into discrete groups with distinct resectability probabilities. A refined recursive partitioning tree composed of three resectability groups was generated, with probabilities of resection and R0 resection of respectively 94 and 73% for group A, 61 and 35% for group B, and 4 and 2% for group C. This resectability scoring system (RSS) was highly prognostic, predicting median overall survival times of 27, 18.9, and 13.5 months respectively for patients in RSS groups A, B, and C (p < 0.001).

conclusionsThe proposed RSS was highly predictive of resection, R0 resection, and prognosis for patients with PC when tested against an external dataset.

Indexed as

AdenocarcinomaPancreatic NeoplasmsHumansRetrospective StudiesTreatment Outcome

Identifiers

PMID36792768
OpenAlexW4320908606

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.