ArticleClinical research in cardiology : official journal of the German Cardiac Society2023
Temporal changes of patient characteristics over 12 years in a single-center transcatheter aortic valve implantation cohort.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Transcatheter Aortic Valve Implantation: Selection, Early Mortality, and Complications. A Multicenter Evaluation of More Than 33 000 Implantations (2013–2023).Deutsches Arzteblatt international · 2026Observational
- VARC-3 defined outcome of valve-in-valve transcatheter aortic valve implantation in stentless compared with stented aortic bioprostheses.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Changes in patient characteristics and procedural measures over a 10-year period in aortic valve-in-valve procedures for degenerated surgical bioprostheses.Frontiers in cardiovascular medicine · 2025Article
- Long-term outcome of patients with severe pulmonary hypertension undergoing transcatheter aortic valve implantation.Frontiers in cardiovascular medicine · 2025Article
- Transcatheter aortic valve implantation (from inception to standard treatment): a single-center observational study.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
16 authors at 1 institution in 1 country.
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Abstract
backgroundBeneficial results of transcatheter aortic valve implantation (TAVI) compared to surgical aortic valve replacement (SAVR) in patients at all risk strata have led to substantial changes in guideline recommendations for valvular heart disease.
aimTo examine influence of these guideline changes on a real-world TAVI cohort, we evaluated how risk profiles and outcomes of TAVI patients developed in our single-center patient cohort over a period of 12 years.
methodsBaseline, procedural and 30-day outcome parameters of TAVI patients were retrospectively compared between three time periods (period 1: 2008-2012, period 2: 2013-2017, period 3: 2018-2020).
resultsBetween 03/2008 and 12/2020, a total of 3678 patients underwent TAVI at our center. The median age was 81.1 years (25th, 75th percentile: 76.7, 84.9) with no significant change over time. The EuroSCORE II showed a continuous and significant decline from 5.3% (3.3, 8.6) in period 1 to 2.8% (1.7, 5.0) in period 3 (p < 0.001). Furthermore, rates of permanent pacemaker implantation, acute kidney injury, and paravalvular leakage ≥ moderate continuously declined over time. Accordingly, the 30-day mortality fell from 9.3% in period 1 to 4.3% in period 3 (p < 0.001).
conclusionDespite substantial guideline alterations, median patient age remained largely unchanged in our TAVI cohort over the past 12 years. Therefore, increased age still appears to be the main reason to choose TAVI over SAVR. However, risk profiles declined substantially. Significant improvements in early outcomes suggest favorable influence of less invasive access routes, improved device platforms and growing user experience.
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