ArticleScientific reports2023
Association of glaucoma and lifestyle with incident cardiovascular disease: a longitudinal prospective study from UK Biobank.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Physical activity and exercise in primary open-angle glaucoma: a scoping review.Frontiers in physiology · 2026Pooled it
- Associations Between Physical Activity and Glaucoma: Analysis of the National Institutes of Health All of Us Research Program.Journal of glaucoma · 2026Article
- Relationships Among Glaucoma, Cardiovascular Diseases, and Mortality.Advances in therapy · 2025Article
- The Pleiotropic Effect of ANRIL in Glaucoma and Cardiovascular Disease.Biomedicines · 2025Article
- Emerging risks of lipid-lowering therapy and low LDL levels: implications for eye, brain, and new-onset diabetes.Lipids in health and disease · 2025Article
- Association of Age-Related Eye Diseases with Comorbidity of Coronary Heart Disease and Depression in a Population-Based Cohort Study.Psychology research and behavior management · 2025Article
- Glaucoma and cardiovascular disease: a bidirectional two-sample Mendelian randomization analysis.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2024Article
- Exploring the Relationship Between Refractive Errors and Common Chronic Diseases Via Blood Biochemistry Tests: A Large Prospective Cohort Study.Investigative ophthalmology & visual science · 2024Article
- Loneliness and social isolation are associated with an increased risk of glaucoma: a UK Biobank cohort study.BMC public health · 2024Article
- High-intensity interval training in patients with glaucoma (HIT-GLAUCOMA): protocol for a multicenter randomized controlled exercise trial.Frontiers in physiology · 2024Article
- Artificial Intelligence Models to Identify Patients with High Probability of Glaucoma Using Electronic Health Records.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The shared pathophysiological features of the cerebrovascular disease (CVD) and glaucoma suggest an association between the two diseases. Using the prospective UK Biobank cohort, we examined the associations between glaucoma and incident CVD and assessed the extent to which a healthy lifestyle reduced the CVD risk in subjects with glaucoma, using a scoring system consisting of four factors: current smoking, obesity, regular physical activity, and a healthy diet. During a mean follow-up time of 8.9 years, 22,649 (4.9%) incident CVD cases were documented. Multivariable Cox regression analyses revealed that subjects with glaucoma were significantly more likely to exhibit incident CVD (hazard ratio [HR]:1.19, 95% confidence interval [CI] 1.03-1.37; p = 0.016) than controls. In the further subgroup analyses, glaucoma increased incident CVD risk both in the young (40-55 years) and the old (56-70 years) and in both sexes, with higher risk in the young (HR: 1.33, CI 1.02-1.74) and female subjects (HR: 1.32, CI 1.14-1.52). When we analyze the associations between glaucoma and incident CVD by lifestyle factors, the highest absolute risks were observed in individuals with both glaucoma and an unhealthy lifestyle (HR: 2.66, CI 2.22-3.19). In conclusion, glaucoma was an independent risk factor for incident CVD. A healthy lifestyle was associated with a substantially lower risk for CVD incidence among adults with glaucoma.
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