Evidence map›Paper›PMID 36792646›Full record

ArticleScientific reports2023

Classification of electrically-evoked potentials in the parkinsonian subthalamic nucleus region.

Joshua Rosing, Alex Doyle, AnneMarie Brinda, Madeline Blumenfeld, Emily Lecy, Chelsea Spencer, Joan Dao, Jordan Krieg, Kelton Wilmerding, Disa Sullivan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Joshua RosingDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Alex DoyleDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
AnneMarie BrindaDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Madeline BlumenfeldDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Emily LecyDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Chelsea SpencerDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Joan DaoDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Jordan KriegDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Kelton WilmerdingDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Disa SullivanDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Sendréa BestDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Biswaranjan MohantyDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Jing WangDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Luke A JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Matthew D JohnsonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. john5101@umn.edu.

Funding

Deep Brain Stimulation in the Parkinsonian MonkeyR01NS037019 · NINDS · UNIVERSITY OF MINNESOTA · PI Jerrold L Vitek · 1999 to 2026
$14.5M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI EBERLY, LYNN E · 2016 to 2020
$9.1M
Spatiotemporal Optimization of Deep Brain Stimulation for Parkinson's DiseaseR01NS094206 · NINDS · UNIVERSITY OF MINNESOTA · PI Matthew Douglas Johnson, THEODEN I NETOFF · 2016 to 2026
$5.6M
The Effects of Parkinsonism and Deep Brain Stimulation on Basal Ganglia-Thalamocortical Circuitry During Sleep-Wake BehaviorR01NS110613 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2019 to 2026
$4.7M
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyR37NS077657 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2018 to 2024
$4.4M
The role of the centromedian and pedunculopontine nuclei in motor function during naïve, parkinsonian and DBS conditionsF31NS108625 · NINDS · UNIVERSITY OF MINNESOTA · PI DOYLE, ALEXANDRA MARIE · 2018 to 2021
$155k
NINDS NIH HHS F31 NS108625NINDS NIH HHS F31-NS108625NINDS NIH HHS P50 NS098573NINDS NIH HHS P50-NS098573NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS037019NINDS NIH HHS R01 NS058945NINDS NIH HHS R01 NS094206NINDS NIH HHS R01-NS094206NINDS NIH HHS R01 NS110613NINDS NIH HHS R37 NS077657
6 · The paper itself

Abstract

Electrically evoked compound action potentials (ECAPs) generated in the subthalamic nucleus (STN) contain features that may be useful for titrating deep brain stimulation (DBS) therapy for Parkinson's disease. Delivering a strong therapeutic effect with DBS therapies, however, relies on selectively targeting neural pathways to avoid inducing side effects. In this study, we investigated the spatiotemporal features of ECAPs in and around the STN across parameter sweeps of stimulation current amplitude, pulse width, and electrode configuration, and used a linear classifier of ECAP responses to predict electrode location. Four non-human primates were implanted unilaterally with either a directional (n = 3) or non-directional (n = 1) DBS lead targeting the sensorimotor STN. ECAP responses were characterized by primary features (within 1.6 ms after a stimulus pulse) and secondary features (between 1.6 and 7.4 ms after a stimulus pulse). Using these features, a linear classifier was able to accurately differentiate electrodes within the STN versus dorsal to the STN in all four subjects. ECAP responses varied systematically with recording and stimulating electrode locations, which provides a subject-specific neuroanatomical basis for selecting electrode configurations in the treatment of Parkinson's disease with DBS therapy.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusAction PotentialsAnimalsEvoked Potentials

Identifiers

PMID36792646
PMCPMC9932154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.