Evidence map›Paper›PMID 36792372›Full record

ArticleGenome research2023

Atlas-scale single-cell chromatin accessibility using nanowell-based combinatorial indexing.

Brendan L O'Connell, Ruth V Nichols, Dmitry Pokholok, Jerushah Thomas, Sonia N Acharya, Andrew Nishida, Casey A Thornton, Marissa Co, Andrew J Fields, Frank J Steemers and 1 more

Abstract read
In one paragraph

Article in Genome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brendan L O'ConnellOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA.
Ruth V NicholsOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA.ORCID 0000-0002-8810-1126
Dmitry PokholokScaleBio, San Diego, California 92121, USA.
Jerushah ThomasScaleBio, San Diego, California 92121, USA.
Sonia N AcharyaOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA.ORCID 0000-0002-3393-397X
Andrew NishidaOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA.
Casey A ThorntonOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA.ORCID 0000-0003-3589-6911
Marissa CoOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA.ORCID 0000-0002-6764-0171
Andrew J FieldsOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA.
Frank J SteemersScaleBio, San Diego, California 92121, USA.
Andrew C AdeyOregon Health & Science University, Department of Molecular and Medical Genetics, Portland, Oregon 97239, USA; adey@ohsu.edu.ORCID 0000-0001-7648-8717

Funding

Defining the epigentic landscape at single cell resolutionR35GM124704 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ADEY, ANDREW · 2017 to 2021
$2.3M
High-content single-cell epigenetic technologies scalable to the human brainRF1MH128842 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI ADEY, ANDREW · 2021 to 2021
$1.9M
Epigenetic tools and resources for cell-type and spatial analysis of individual mammalian non-neuronal cellsR01DA047237 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ADEY, ANDREW · 2018 to 2020
$1.7M
NIDA NIH HHS R01 DA047237NIGMS NIH HHS R35 GM124704NIMH NIH HHS RF1 MH128842
6 · The paper itself

Abstract

Here we present advancements in single-cell combinatorial indexed Assay for Transposase Accessible Chromatin (sciATAC) to measure chromatin accessibility that leverage nanowell chips to achieve atlas-scale cell throughput (>10

Indexed as

ChromatinTransposasesAnimalsEpigenomicsMiceNeuronsSingle-Cell AnalysisChromatinTransposases

Identifiers

PMID36792372
PMCPMC10069466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.