Evidence map›Paper›PMID 36792338›Full record

Observational studyBMJ open2023

Feeding practices and growth patterns of moderately low birthweight infants in resource-limited settings: results from a multisite, longitudinal observational study.

Linda Vesel, Roopa M Bellad, Karim Manji, Friday Saidi, Esther Velasquez, Christopher R Sudfeld, Katharine Miller, Mohamed Bakari, Kristina Lugangira, Rodrick Kisenge and 38 more

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04002908 (Low-birthweight Infant Feeding Exploration), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04002908 completednot on this map

Low-birthweight Infant Feeding Exploration

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2019 to 2021Enrolled3,188ConditionsLow Birthweight, Pre-Term
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 13 institutions in 4 countries.

Linda VeselAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA lvesel@ariadnelabs.org.ORCID 0000-0003-3753-4172
Roopa M BelladJawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belgaum, Karnataka, India.
Karim ManjiDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0002-7069-6408
Friday SaidiUniversity of North Carolina Project Malawi, Lilongwe, Malawi.ORCID 0000-0003-1190-1499
Esther VelasquezDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, California, USA.
Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-3203-3638
Katharine MillerAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mohamed BakariDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Kristina LugangiraDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Rodrick KisengeDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Nahya SalimDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Sarah SomjiDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Irving HoffmanInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Kingsly MsimukoUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Tisungane MvaloUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Fadire NyirendaUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Melda PhiriUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Leena DasDepartment of Paediatrics, SCB Medical College & Hospital, Cuttack, Orissa, India.
Sangappa DhadedJawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belgaum, Karnataka, India.ORCID 0000-0001-9575-5251
Shivaprasad S GoudarJawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belgaum, Karnataka, India.
Veena HerekarJawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belgaum, Karnataka, India.
Yogesh KumarJawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belgaum, Karnataka, India.
M B KoujalagiDepartment of Paediatrics, JJM Medical College, Davangere, Karnataka, India.
Gowdar GuruprasadDepartment of Paediatrics, JJM Medical College, Davangere, Karnataka, India.
Sanghamitra PandaDepartment of Paediatrics, City Hospital, Cuttack, Orissa, India.
Latha G ShamanurDepartment of Paediatrics, SS Institute of Medical Sciences and Research Center, Davangere, Karnataka, India.
Manjunath SomannavarJawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belgaum, Karnataka, India.
Sunil S VernekarJawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belgaum, Karnataka, India.
Sujata MisraDepartment of Paediatrics, SCB Medical College & Hospital, Cuttack, Orissa, India.
Linda AdairDepartment of Nutrition, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.
Griffith BellAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Bethany A CarusoHubert Department of Global Health, Emory University School of Public Health, Atlanta, Georgia, USA.
Christopher DugganCenter for Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Katelyn FlemingAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kiersten Israel-BallardMaternal, Newborn, Child Health and Nutrition Program, PATH, Seattle, Washington, USA.
Eliza FishmanAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Anne C C LeeDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-2654-9862
Stuart LipsitzAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kimberly L MansenMaternal, Newborn, Child Health and Nutrition Program, PATH, Seattle, Washington, USA.
Stephanie L MartinDepartment of Nutrition, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.
Rana R MokhtarAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Krysten NorthDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Arthur PoteAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Lauren SpigelAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Danielle E TullerAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.
Melissa YoungHubert Department of Global Health, Emory University School of Public Health, Atlanta, Georgia, USA.
Katherine E A SemrauAriadne Labs, Harvard T.H. Chan School of Public Health / Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-8360-1391
LIFE study team
Brigham and Women's Hospital · USJawaharlal Nehru Medical College · INMuhimbili University of Health and Allied Sciences · TZUniversity of Malawi · MWUniversity of North Carolina at Chapel Hill · USEmory University · USJSS Medical College and Hospital · INProgram for Appropriate Technology in Health · USSriram Chandra Bhanja Medical College Hospital · INBoston Children's Hospital · USHarvard Global Health Institute · USShamnur Shivashankarappa Institute of Medical Sciences & Research Centre · INStanford University · US

Funding

Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
The Roles of Perinatal Nutrition, Infection and Inflammation in the Neurodevelopment of Bangladeshi InfantsK23HD091390 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, ANNE SHEE CC · 2017 to 2021
$864k
Gates Foundation INV-007326NICHD NIH HHS K23 HD091390NICHD NIH HHS P2C HD050924
6 · The paper itself

Abstract

objectivesTo describe the feeding profile of low birthweight (LBW) infants in the first half of infancy; and to examine growth patterns and early risk factors of poor 6-month growth outcomes.

designProspective observational cohort study. SETTING AND

participantsStable, moderately LBW (1.50 to <2.50 kg) infants were enrolled at birth from 12 secondary/tertiary facilities in India, Malawi and Tanzania and visited nine times over 6 months. VARIABLES OF INTEREST: Key variables of interest included birth weight, LBW type (combination of preterm/term status and size-for-gestational age at birth), lactation practices and support, feeding profile, birthweight regain by 2 weeks of age and poor 6-month growth outcomes.

resultsBetween 13 September 2019 and 27 January 2021, 1114 infants were enrolled, comprising 4 LBW types. 363 (37.3%) infants initiated early breast feeding and 425 (43.8%) were exclusively breastfed to 6 months. 231 (22.3%) did not regain birthweight by 2 weeks; at 6 months, 280 (32.6%) were stunted, 222 (25.8%) underweight and 88 (10.2%) wasted. Preterm-small-for-gestational age (SGA) infants had 1.89 (95% CI 1.37 to 2.62) and 2.32 (95% CI 1.48 to 3.62) times greater risks of being stunted and underweight at 6 months compared with preterm-appropriate-for-gestational age (AGA) infants. Term-SGA infants had 2.33 (95% CI 1.77 to 3.08), 2.89 (95% CI 1.97 to 4.24) and 1.99 (95% CI 1.13 to 3.51) times higher risks of being stunted, underweight and wasted compared with preterm-AGA infants. Those not regaining their birthweight by 2 weeks had 1.51 (95% CI 1.23 to 1.85) and 1.55 (95% CI 1.21 to 1.99) times greater risks of being stunted and underweight compared with infants regaining.

conclusionLBW type, particularly SGA regardless of preterm or term status, and lack of birthweight regain by 2 weeks are important risk identification parameters. Early interventions are needed that include optimal feeding support, action-oriented growth monitoring and understanding of the needs and growth patterns of SGA infants to enable appropriate weight gain and proactive management of vulnerable infants. TRIAL REGISTRATION NUMBER: NCT04002908.

Indexed as

Infant, Low Birth WeightThinnessBirth WeightCachexiaFemaleHumansInfantInfant, NewbornInfant, PrematureInfant, Small for Gestational AgeProspective Studiescommunity child healthepidemiologyneonatologynutrition & dieteticspublic health

Identifiers

PMID36792338
PMCPMC9933750
OpenAlexW4320912970

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.