Evidence map›Paper›PMID 36792333›Full record

ArticleBMJ open2023

Scaling-up high-impact micronutrient supplementation interventions to improve adolescents' nutrition and health in Burkina Faso and Tanzania: protocol for a cluster-randomised controlled trial.

Ilana Rachel Cliffer, Mashavu H Yussuf, Ourohire Millogo, Mary Mwanyika-Sando, Yllassa Barry, Innocent S Yusufu, Elena Cori Hemler, Ali Sie, Amani Tinkasimile, Guillaume Compaoré and 5 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04657640 phase3completednot on this map

Scaling-up High-impact Micronutrient Supplementation Interventions to Improve Adolescents' Nutrition and Health in Burkina Faso

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2020 to 2024Enrolled3,123ConditionsAnemiaArmsIron and folic acid (IFA), Multiple Micronutrient Supplements (MMS) and loading dose of Iron and Folic Acid (IFA)
NCT05104554 nacompletednot on this map

School-Based Assessment of Micronutrient Interventions in Adolescents (SAMIA) in Zanzibar

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2022 to 2023Enrolled2,480ConditionsAnemiaArmsIron and folic acid (IFA), Multiple Micronutrient Supplement (MMS)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Ilana Rachel ClifferDepartment of Global Health and Population, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA icliffer@hsph.harvard.edu.ORCID 0000-0002-0740-787X
Mashavu H YussufAfrica Academy for Public Health, Dar es Salaam, United Republic of Tanzania.
Ourohire MillogoCentre de Recherche en Sante de Nouna, Nouna, Boucle du Mouhoun, Burkina Faso.ORCID 0000-0002-2552-8122
Mary Mwanyika-SandoAfrica Academy for Public Health, Dar es Salaam, United Republic of Tanzania.
Yllassa BarryNouna Health Research Center, Nouna, Burkina Faso.
Innocent S YusufuAfrica Academy for Public Health, Dar es Salaam, United Republic of Tanzania.
Elena Cori HemlerGlobal Health and Population, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Ali SieCentre de Recherche en Sante de Nouna, Nouna, Boucle du Mouhoun, Burkina Faso.
Amani TinkasimileAfrica Academy for Public Health, Dar es Salaam, United Republic of Tanzania.
Guillaume CompaoréCentre de Recherche en Sante de Nouna, Nouna, Boucle du Mouhoun, Burkina Faso.
Ali Salim AliZanzibar Association for People Living with HIV/AIDS, Zanzibar, United Republic of Tanzania.
Idrissa KouandaCentre de Recherche en Sante de Nouna, Nouna, Boucle du Mouhoun, Burkina Faso.
Dongqing WangGlobal Health and Population, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-3369-5972
Dominic MoshaAfrica Academy for Public Health, Dar es Salaam, United Republic of Tanzania.
Wafaie FawziGlobal Health and Population, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-2908-600X
Africa Academy for Public Health · TZCentre de Recherche en Santé de Nouna · BFHarvard University · USZanzibar University · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdolescence is a critical time for growth and development, but this age group is often neglected in research and development of nutrition interventions. Despite recommendations from the WHO to provide nutrient supplements to adolescents, evidence remains scarce on the most effective supplementation strategy. This study aims to compare weekly iron and folic acid (IFA) supplementation with daily multiple micronutrient supplements (MMSs) in prevention of anaemia and improvement of school outcomes among adolescents in Burkina Faso and Tanzania. METHODS AND ANALYSIS: A three-arm cluster-randomised, school-based supplementation trial will be conducted among 84 schools (42 schools per site) and roughly 4500 students aged 10-17. Schools will be matched on three characteristics: number of students, school ranking profile, distance to main road (Tanzania) or distance to city council (Burkina Faso). Each school will be randomised to receive either weekly IFA, daily MMSs or serve as a control. Supplements will be delivered to students by teachers, who will provide monitoring data to the study team. Baseline and endline surveys will be conducted prior to and after each supplementation cycle (12 weeks in Burkina Faso; 1 year in Tanzania) to assess haemoglobin, anthropometry and sociodemographic variables. The primary outcome of haemoglobin will be analysed continuously using linear regression, and anaemia status will be analysed using logistic or multinomial regression, depending on categorisation level of the outcome. Secondary analyses of school performance indicators will also be conducted with either logistic or linear regression. ETHICS AND DISSEMINATION: This protocol has been approved by the Institutional Review Board of the Harvard TH Chan School of Public Health (IRB20-1108) and the Research Ethics Committees for the Ministries of Health in Tanzania (Zanzibar) and Burkina Faso. Results will be disseminated during meetings with the Ministries of Health and the participating communities as well as through peer-reviewed publications. TRIAL REGISTRATION NUMBER: NCT04657640; NCT05104554.

Indexed as

AnemiaFolic AcidAdolescentBurkina FasoDietary SupplementsHumansIronMicronutrientsRandomized Controlled Trials as TopicTanzaniaFolic AcidIronMicronutrientsanaemiacommunity child healthnutritionpublic health

Identifiers

PMID36792333
PMCPMC9933747
OpenAlexW4320912917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.