ArticleOpen heart2023
Atrial functional mitral regurgitation: prevalence, characteristics and outcomes from the National Echo Database of Australia.
Article in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Gender Differences in Cardiac Organ Damage in Arterial Hypertension: Assessing the Role of Drug Nonadherence.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Trial
- 2025 ESC/EACTS valvular heart disease guidelines: practical updates on mitral and tricuspid regurgitation.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Atrial Secondary Mitral Regurgitation: Pathophysiology, Diagnosis, and Surgical Implications.Medicina (Kaunas, Lithuania) · 2026Review
- Atrial Secondary Mitral Regurgitation Outcomes Following Mitral Transcatheter Edge-to-Edge Repair: Results From the EXPANDed Studies.Circulation. Cardiovascular interventions · 2026Article
- The Prognosis of Males and Females With Moderate or Severe Secondary Mitral Valve Regurgitation and Avenues for Improvement.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Epidemiology, pathophysiology, diagnosis and management of atrial functional mitral regurgitation: An expert opinion paper.ESC heart failure · 2025Review
- Outcomes of Mitral Valve Surgery for Atrial Functional Mitral Regurgitation vs Ventricular Functional Mitral Regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Association of Left Atrial Function With Mitral Regurgitation: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2025Observational
- A novel nomogram model for diagnosing isolated atrial functional mitral regurgitation in patients with significant functional mitral regurgitation.Quantitative imaging in medicine and surgery · 2025Article
- Epidemiology of Valvular Heart Disease in Asia Pacific Region.JACC. Asia · 2025Review
- Mortality associated with moderate and severe mitral regurgitation in 608 570 men and women undergoing echocardiography.Heart (British Cardiac Society) · 2025Article
- Atrial Functional Mitral Regurgitation: From Diagnosis to Current Interventional Therapies.Journal of clinical medicine · 2024Review
- Unique Aspects of Women's Valvular Heart Diseases: Impact for Diagnosis and Treatment.CJC open · 2024Review
- Unraveling the interplay: early-stage atrial functional mitral regurgitation and left atrial electrical substrate in atrial fibrillation patients.Frontiers in cardiovascular medicine · 2024Article
- Left Atrium: A New Prognostic Marker and Therapeutic Target in Secondary Mitral Regurgitation?European cardiology · 2024Review
- Atrial functional mitral regurgitation: was this new entity needed?REC, interventional cardiologyReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAtrial functional mitral regurgitation (AFMR) is characterised by left atrial and consequent mitral annular dilatation causing mitral regurgitation. AFMR is likely to become more common with population ageing, alongside increases in atrial fibrillation and heart failure with preserved ejection fraction; conditions causing atrial dilatation. Here, we aim to define the prevalence and characterise the patient and survival characteristics of AFMR in the National Echocardiographic Database of Australia (NEDA). METHODS AND
results14 004 adults with moderate or severe FMR were identified from NEDA. AFMR or ventricular FMR (VFMR) was classified by LA size, LV size and LVEF. AFMR was found in 40% (n=5562) and VFMR in 60% (n=8442). Compared with VFMR, the AFMR subgroup were significantly older (mean age 78±11 years), with a higher proportion of females and of AF. Participants were followed up for a median of 65 months (IQR 36-116 months). After adjustment for age, sex, AF, and pulmonary hypertension, the prognosis for VFMR was significantly worse than for AFMR (HR 1.57, 95% CI 1.47 to 1.68 for all-cause and 1.73, 95% CI 1.60 to 1.88, p<0.001 for both). After further adjustment for LVEF, mortality rates were similar in VFMR and AFMR patients (HR 0.93, p=NS), though advancing age and pulmonary hypertension remained independently associated with prognosis.
conclusionsAFMR is a common cause of significant functional MR that predominantly affects elderly female patients with AF. Advancing age and pulmonary hypertension independently associated with survival in FMR. Prognosis was better in AFMR compared with VFMR; however, this difference was accounted for by LV systolic impairment and not by MR severity.
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