Evidence map›Paper›PMID 36791398›Full record

ArticleJournal of agricultural and food chemistry2023

Interactions in Aqueous Mixtures of Cationic Hydroxyethyl Cellulose and Different Anionic Bile Salts.

Julia Jianwei Tan, Natalie Gjerde, Alessandra Del Giudice, Kenneth D Knudsen, Luciano Galantini, Guanqun Du, Karin Schillén, Sverre Arne Sande, Bo Nyström

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Julia Jianwei TanSchool of Pharmacy, Department of Pharmaceutics, University of Oslo, P.O. Box 1068, Blindern, N-0316 Oslo, Norway.
Natalie GjerdeDepartment of Chemistry, ''Sapienza'' University of Rome, P.O. Box 34, Roma 62, Piazzale A. Moro 5, I-00185 Roma, Italy.
Alessandra Del GiudiceDepartment of Chemistry, ''Sapienza'' University of Rome, P.O. Box 34, Roma 62, Piazzale A. Moro 5, I-00185 Roma, Italy.ORCID 0000-0002-1916-8300
Kenneth D KnudsenInstitute for Energy Technology, P.O. Box 40, N-2027 Kjeller, Norway.
Luciano GalantiniDepartment of Chemistry, ''Sapienza'' University of Rome, P.O. Box 34, Roma 62, Piazzale A. Moro 5, I-00185 Roma, Italy.ORCID 0000-0001-5484-2658
Guanqun DuDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
Karin SchillénDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.ORCID 0000-0001-8147-1733
Sverre Arne SandeSchool of Pharmacy, Department of Pharmaceutics, University of Oslo, P.O. Box 1068, Blindern, N-0316 Oslo, Norway.
Bo NyströmDepartment of Chemistry, University of Oslo, P.O. Box 1033, Blindern, N-0315 Oslo, Norway.ORCID 0000-0002-6903-4423
Sapienza University of Rome · ITUniversity of Oslo · NOLund University · SEInstitute for Energy Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is known that the reduction of blood cholesterol can be accomplished through foods containing a large number of dietary fibers; this process is partially related to the binding of bile salt to fibers. To gain new insights into the interactions between dietary fibers and bile salts, this study investigates the interactions between cationic hydroxyethyl cellulose (catHEC) and sodium deoxycholate (NaDC) or sodium cholate (NaC), which have a similar structure. Turbidity measurements reveal strong interactions between catHEC and NaDC, and under some conditions, macroscopic phase separation occurs. In contrast, the interactions with NaC are weak. At a catHEC concentration of 2 wt %, incipient phase separation is approached at concentrations of NaC and NaDC of 32.5 and 19.3 mM, respectively. The rheological results show strong interactions and a prominent viscosification effect for the catHEC/NaDC system but only moderate interactions for the catHEC/NaC system. Both cryogenic transmission electron microscopy and small-angle X-ray scattering results display fundamental structural differences between the two systems, which may explain the stronger interactions in the presence of NaDC. The surmise is that the extended structures formed in the presence of NaDC can easily form connections and entanglements in the network.

Indexed as

Bile Acids and SaltsDeoxycholic AcidCelluloseDietary FiberMicellesBile Acids and SaltsCelluloseDeoxycholic AcidDietary FiberMicellesbile saltscationic hydroxyethyl cellulosecryo-TEMinteractionsrheologySAXS

Identifiers

PMID36791398
PMCPMC9983013
OpenAlexW4320892380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.