Evidence map›Paper›PMID 36791332›Full record

ArticleACS chemical biology2023

Mechanistic Insight into the Suppression of Polyglutamine Aggregation by SRCP1.

Holly N Haver, Michael Wedemeyer, Erin Butcher, Francis C Peterson, Brian F Volkman, K Matthew Scaglione

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Cell biology of Dictyostelium.BMC molecular and cell biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Holly N HaverDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina 27710, United States.
Michael WedemeyerDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Erin ButcherDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina 27710, United States.
Francis C PetersonDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Brian F VolkmanDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0002-6681-5179
K Matthew ScaglioneDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina 27710, United States.ORCID 0000-0002-3858-9418
Duke University · USMedical College of Wisconsin · US

Funding

Investigation into protein quality control pathways in Dictyostetlium discoideumR35GM119544 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI Kenneth Matthew Scaglione · 2016 to 2026
$4.2M
Structural Basis for Chemokine FunctionR37AI058072 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Brian F Volkman · 2020 to 2026
$2.8M
Novel chaperones and neurodegenerationR01NS112191 · NINDS · DUKE UNIVERSITY · PI SCAGLIONE, KENNETH MATTHEW · 2019 to 2023
$2.4M
800 MHz NMR Spectrometer for Southeast WisconsinS10OD025000 · OD · MEDICAL COLLEGE OF WISCONSIN · PI VOLKMAN, BRIAN F · 2019 to 2019
$2.0M
NIAID NIH HHS R37 AI058072NIGMS NIH HHS R35 GM119544NIH HHS S10 OD025000NINDS NIH HHS R01 NS112191
6 · The paper itself

Abstract

Protein aggregation is a hallmark of the polyglutamine diseases. One potential treatment for these diseases is suppression of polyglutamine aggregation. Previous work identified the cellular slime mold

Indexed as

DictyosteliumProtein AggregatesHumansHuntingtin ProteinMolecular ChaperonesPeptidesSerineHuntingtin ProteinMolecular ChaperonesPeptidespolyglutamineProtein AggregatesSerine

Identifiers

PMID36791332
PMCPMC10023506
OpenAlexW4320895576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.