Evidence map›Paper›PMID 36791208›Full record

ArticleScience translational medicine2023

Data-driven longitudinal characterization of neonatal health and morbidity.

Davide De Francesco, Jonathan D Reiss, Jacquelyn Roger, Alice S Tang, Alan L Chang, Martin Becker, Thanaphong Phongpreecha, Camilo Espinosa, Susanna Morin, Eloïse Berson and 23 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. A lesson from the past and the future of artificial intelligence in medical decision-making.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  3. Article
  4. Article
  5. [Research progress in artificial intelligence for the diagnosis and management of diseases in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Towards a new taxonomy of preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Mitigation of outcome conflation in predicting patient outcomes using electronic health records.Journal of the American Medical Informatics Association : JAMIA · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 3 institutions in 1 country.

Davide De FrancescoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6185-0514
Jonathan D ReissDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1460-8570
Jacquelyn RogerBakar Computational Health Sciences Institute, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-1823-0421
Alice S TangBakar Computational Health Sciences Institute, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-4745-0714
Alan L ChangDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1716-0134
Martin BeckerDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-4296-3481
Thanaphong PhongpreechaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-9245-6686
Camilo EspinosaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1630-1564
Susanna MorinBakar Computational Health Sciences Institute, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-2008-2950
Eloïse BersonDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1046-125X
Melan ThuraiappahDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6412-6222
Brian L LeBakar Computational Health Sciences Institute, University of California, San Francisco, CA 94143, USA.
Neal G RavindraDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-5558-3758
Seyedeh Neelufar PayrovnaziriDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-4712-9648
Samson MatarasoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-3146-2243
Yeasul KimDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-8289-1297
Lei XueDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-4236-8714
Melissa G RosensteinDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94158, USA.
Tomiko OskotskyBakar Computational Health Sciences Institute, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-7393-5120
Ivana MarićDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9441-521X
Brice GaudilliereDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-3475-5706
Brendan CarvalhoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-4919-4542
Brian T BatemanDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Martin S AngstDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-1550-8136
Lawrence S PrinceDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7010-4548
Yair J BlumenfeldDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.
William E BenitzDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-3645-3346
Janene H FuerchDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-2450-9074
Gary M ShawDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-7438-4914
Karl G SylvesterDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-7246-6083
Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6117-8764
Stanford University · USUniversity of California, San Francisco · USUniversity of California San Francisco Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Lisa Goldman Rosas · 2020 to 2026
$29.0M
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Preeclampsia to cardiovascular disease: Life course analysis of biomarkers and riskR01HL139844 · NHLBI · STANFORD UNIVERSITY · PI HLATKY, MARK A., WINN, VIRGINIA D · 2018 to 2021
$9.0M
UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community EngagementP01HD106414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAUDILLIERE, BRICE, GIUDICE, LINDA C · 2021 to 2025
$7.1M
Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)R01HD105256 · NICHD · STANFORD UNIVERSITY · PI LATHI, RUTH B, RAJKOVIC, ALEKSANDAR · 2021 to 2025
$7.0M
BMI Bioinformatics Training GrantsT32GM067547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2003 to 2022
$6.6M
SPRINT: Signature for Pain Recovery IN TeensR61NS114926 · NINDS · STANFORD UNIVERSITY · PI SIMONS, LAURA E · 2019 to 2019
$5.4M
Dietary Modulation of Neuroinflammation in Age-Related Memory DisordersR01AG058417 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SLOAN, RICHARD P, SMALL, SCOTT A · 2018 to 2022
$4.2M
Machine Learning for Integrative Modeling of the Immune System in Clinical SettingsR35GM138353 · NIGMS · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA · 2020 to 2024
$2.2M
NHLBI NIH HHS R01 HL139844NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG058417NICHD NIH HHS P01 HD106414NICHD NIH HHS R01 HD105256NIGMS NIH HHS R35 GM138353NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM067547NINDS NIH HHS R61 NS114926NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

Although prematurity is the single largest cause of death in children under 5 years of age, the current definition of prematurity, based on gestational age, lacks the precision needed for guiding care decisions. Here, we propose a longitudinal risk assessment for adverse neonatal outcomes in newborns based on a deep learning model that uses electronic health records (EHRs) to predict a wide range of outcomes over a period starting shortly before conception and ending months after birth. By linking the EHRs of the Lucile Packard Children's Hospital and the Stanford Healthcare Adult Hospital, we developed a cohort of 22,104 mother-newborn dyads delivered between 2014 and 2018. Maternal and newborn EHRs were extracted and used to train a multi-input multitask deep learning model, featuring a long short-term memory neural network, to predict 24 different neonatal outcomes. An additional cohort of 10,250 mother-newborn dyads delivered at the same Stanford Hospitals from 2019 to September 2020 was used to validate the model. Areas under the receiver operating characteristic curve at delivery exceeded 0.9 for 10 of the 24 neonatal outcomes considered and were between 0.8 and 0.9 for 7 additional outcomes. Moreover, comprehensive association analysis identified multiple known associations between various maternal and neonatal features and specific neonatal outcomes. This study used linked EHRs from more than 30,000 mother-newborn dyads and would serve as a resource for the investigation and prediction of neonatal outcomes. An interactive website is available for independent investigators to leverage this unique dataset: https://maternal-child-health-associations.shinyapps.io/shiny_app/.

Indexed as

Infant HealthInfant, PrematureAdultChildChild, PreschoolGestational AgeHumansInfant, NewbornMorbidityRisk Assessment

Identifiers

PMID36791208
PMCPMC10197092
OpenAlexW4320896617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.