ArticleScience advances2023
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation.
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In one paragraph
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
What it found
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Review
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- Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces.Bioengineering & translational medicine · 2026Article
- Advances in genetics, signaling, and modeling of venous malformations.Frontiers in cardiovascular medicine · 2026Review
- Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP-Mediated Mechanosensitization of Intestinal Epithelial Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations.APL bioengineering · 2025Article
- The immunoregulatory role of integrins in pulmonary diseases.Frontiers in immunology · 2025Review
- Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations.bioRxiv : the preprint server for biology · 2024Article
- Human Cell-Derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature-on-chip Models.Advanced healthcare materials · 2024Article
- Vascular microphysiological systems.Current opinion in hematology · 2024Review
- Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling.Expert opinion on drug discovery · 2024Review
- Engineering Organ-on-a-Chip Systems for Vascular Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- A facile fluid pressure system reveals differential cellular response to interstitial pressure gradients and flow.Biomicrofluidics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Wen Yih AwJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0002-1724-412X
Crescentia ChoJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0003-4753-802X
Hao WangJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0001-9976-9247
Anne Hope CooperJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.
Elizabeth L DohertyJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0002-4793-2695
David RoccoDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-2580-1790
Stephanie A HuangJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0003-2466-9174
Sarah KubikJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0002-1699-1422
Chloe P WhitworthJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0001-5726-6158
Ryan ArmstrongDepartment of Physics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anthony J HickeyUNC Catalyst for Rare Diseases, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Boyce GriffithJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0002-9800-7504
Matthew L KutysDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0752-649X
Julie BlattDepartment of Pediatrics (Division of Pediatric Hematology Oncology), University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7658-8096
William J PolacheckJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and North Carolina State University, Raleigh, NC, USA.ORCID 0000-0003-2728-0746
University of North Carolina at Chapel Hill · USUniversity of California, San Francisco · US
Funding
Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7MRENAL EPIDEMIOLOGY TRAINING PROGRAMT32DK007750 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FALK, RONALD J · 1999 to 2022
$5.5MIntegrative Approaches for the Study of the Fluidic Cellular MicroenvironmentR35GM142944 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William J Polacheck · 2021 to 2026
$2.3MTraining Grant in Comparative Molecular MedicineT32GM133393 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Matthew B Fisher, Caroline Laplante · 2021 to 2026
$1.7MDefining the role of extracellular matrix mechanics in vascular Ehlers-Danlos syndromeF31HL162462 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOHERTY, ELIZABETH LOUISE · 2022 to 2023
$73kNHLBI NIH HHS F31 HL162462NHLBI NIH HHS T32 HL069768NIDDK NIH HHS T32 DK007750NIGMS NIH HHS R35 GM142944NIGMS NIH HHS T32 GM133393
Abstract
Somatic activating mutations of
Indexed as
TOR Serine-Threonine KinasesVascular MalformationsClass I Phosphatidylinositol 3-KinasesHumansHuman Umbilical Vein Endothelial CellsMechanistic Target of Rapamycin Complex 1Mitogen-Activated Protein Kinase Kinasesrac1 GTP-Binding ProteinSirolimusClass I Phosphatidylinositol 3-KinasesMechanistic Target of Rapamycin Complex 1Mitogen-Activated Protein Kinase KinasesPIK3CA protein, humanrac1 GTP-Binding ProteinRAC1 protein, humanSirolimusTOR Serine-Threonine Kinases
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.