SynthesisCurrent oncology reports2023
Diagnostic Accuracy of Liquid Biopsy for Oral Potentially Malignant Disorders and Head and Neck Cancer: an Overview of Systematic Reviews.
Synthesis in Current oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Non-invasive detection and monitoring of oral squamous cell carcinoma and oral potentially malignant disorders: an umbrella review on diagnostic accuracy.Clinical oral investigations · 2026Pooled it
- miR-185 in salivary extracellular vesicles for early diagnosis of malignant transformation in oral leukoplakia: a clinical study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Artificial intelligence in head and neck cancer: a bibliometric and visualization analysis (1995-2025).Discover oncology · 2025Article
- Potential use of liquid biopsy in diagnosing oral malignancies.Bioinformation · 2025Article
- The pursuit of novel head and neck cancer biomarkers - tissue and blood expression of chloride intracellular channels family.PloS one · 2025Article
- The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine.Cancers · 2024Review
- Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine.Cancer science · 2024Review
- Circulating tumor DNA in head and neck squamous cell carcinoma-current status and future prospects.Academia oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThe aim of this overview is to appraise the evidence on salivary biomarkers for H&N cancer diagnosis. The acronym PICOS was used to develop the eligibility criteria and the focused review question: are liquid biopsies (saliva biomarkers) reliable for cancer detection in H&N cancer patients? Electronic database search encompassed PubMed, EMBASE, Scopus, Cochrane Library, Web of Science, and LILACS. Risk of Bias (RoB) was assessed through AMSTAR 2. RECENT
findingsA total of 20 SRs were included. Only seven SRs were able to reach more solid conclusions around the retrieved findings by calculating the pooled sensitivity, specificity, and the overall area under the curve (AUC). Despite the limitations, significant RoB, and lack of test metrics in primary studies, all SRs recognize and encourage the potential role of saliva in the early diagnosis of oral cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.