Evidence map›Paper›PMID 36790618›Full record

ReviewCurrent cardiology reports2023

Recent Advances in Serum Biomarkers for Risk Stratification and Patient Management in Cardio-Oncology.

Pouya Joolharzadeh, Mario Rodriguez, Raja Zaghlol, Lauren N Pedersen, Jesus Jimenez, Carmen Bergom, Joshua D Mitchell

Open access · hybridAbstract readReview
In one paragraph

Review in Current cardiology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  3. Non-Oncology Biomarkers in Precision Medicine: A Narrative Review.Therapeutic innovation & regulatory science · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pouya JoolharzadehGeneral Medical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Mario RodriguezCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Raja ZaghlolCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Lauren N PedersenCardio-Oncology Center of Excellence, Washington University School of Medicine, St. Louis, MO, USA.
Jesus JimenezCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Carmen BergomCardio-Oncology Center of Excellence, Washington University School of Medicine, St. Louis, MO, USA.
Joshua D MitchellCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. jdmitchell@wustl.edu.ORCID 0000-0001-7371-5742
Washington University in St. Louis · USGeneral Sciences (United States) · US

Funding

Genetic Modifiers of Radiation Therapy-Induced CardiotoxicityR01HL147884 · NHLBI · WASHINGTON UNIVERSITY · PI BERGOM, CARMEN · 2019 to 2023
$2.3M
NHLBI NIH HHS R01 HL147884
6 · The paper itself

Abstract

purpose of reviewFollowing significant advancements in cancer therapeutics and survival, the risk of cancer therapy-related cardiotoxicity (CTRC) is increasingly recognized. With ongoing efforts to reduce cardiovascular morbidity and mortality in cancer patients and survivors, cardiac biomarkers have been studied for both risk stratification and monitoring during and after therapy to detect subclinical disease. This article will review the utility for biomarker use throughout the cancer care continuum. RECENT

findingsA recent meta-analysis shows utility for troponin in monitoring patients at risk for CTRC during cancer therapy. The role for natriuretic peptides is less clear but may be useful in patients receiving proteasome inhibitors. Early studies explore use of myeloperoxidase, growth differentiation factor 15, galectin 3, micro-RNA, and others as novel biomarkers in CTRC. Biomarkers have potential to identify subclinical CTRC and may reveal opportunities for early intervention. Further research is needed to elucidate optimal biomarkers and surveillance strategies.

Indexed as

Antineoplastic AgentsHeart DiseasesNeoplasmsBiomarkersCardiotoxicityHumansMedical OncologyRisk AssessmentAntineoplastic AgentsBiomarkersBiomarkersCancer therapyCardio-oncologyCardiotoxicityRisk predictionScreening

Identifiers

PMID36790618
PMCPMC9930715
OpenAlexW4320857052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.