Evidence map›Paper›PMID 36790613›Full record

ArticleJournal of pharmacokinetics and pharmacodynamics2023

Mechanistic inference of the metabolic rates underlying

Andrew F Brouwer, Gwenyth O Lee, Robert J Schillinger, Christine A Edwards, Hannah Van Wyk, Roger Yazbeck, Douglas J Morrison

Open access · greenAbstract read
In one paragraph

Article in Journal of pharmacokinetics and pharmacodynamics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Associations ofCurrent developments in nutrition · 2025
    Article
  3. A cross-sectional study of associations between theThe American journal of clinical nutrition · 2024
    Observational
  4. Article
  5. A Model-BasedThe Journal of nutrition · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Andrew F BrouwerDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, 48109, MI, United States.ORCID 0000-0002-3779-5287
Gwenyth O LeeDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, 48109, MI, United States.ORCID 0000-0002-7889-3852
Robert J SchillingerScottish Universities Environmental Research Centre, University of Glasgow, Rankine Avenue, East Kilbride, G75 0QF, United Kingdom.
Christine A EdwardsSchool of Medicine, Dentistry and Nursing, University of Glasgow, University Ave, Glasgow, G12 8QQ, United Kingdom.ORCID 0000-0003-0406-918X
Hannah Van WykDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, 48109, MI, United States.ORCID 0000-0002-3495-0085
Roger YazbeckCollege of Medicine and Public Health, Flinders University, University Ave, Adelaide, 5001, South Australia.
Douglas J MorrisonScottish Universities Environmental Research Centre, University of Glasgow, Rankine Avenue, East Kilbride, G75 0QF, United Kingdom.ORCID 0000-0002-4161-5699
University of Michigan · USScottish Universities Environmental Research Centre · GBFlinders University · AUUniversity of Glasgow · GB

Funding

Dynamic modeling of antagonism between enteric infection and undernutritionin infancyK01AI145080 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEE, GWENYTH O'NEILL · 2020 to 2024
$570k
NIAID NIH HHS K01 AI145080
6 · The paper itself

Abstract

Carbon stable isotope breath tests offer new opportunities to better understand gastrointestinal function in health and disease. However, it is often not clear how to isolate information about a gastrointestinal or metabolic process of interest from a breath test curve, and it is generally unknown how well summary statistics from empirical curve fitting correlate with underlying biological rates. We developed a framework that can be used to make mechanistic inference about the metabolic rates underlying a

Indexed as

Breath TestsAdultCarbon IsotopesHumansPilot ProjectsCarbon IsotopesBreath testCarbon-13Environmental enteric dysfunctionIdentifiabilityStable isotopeSucrose

Identifiers

PMID36790613
PMCPMC10544773
OpenAlexW4320857558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.