ArticleEating and weight disorders : EWD2023
Genetically predicted obesity and risk of hip osteoarthritis.
Article in Eating and weight disorders : EWD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Cam morphology and the risk of developing radiographic hip osteoarthritis within 8 years: an individual participant data meta-analysis of 23 886 hips from the world COACH consortium.British journal of sports medicine · 2026Pooled it
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Impact of Prior Metabolic and Bariatric Surgery on Outcomes of Total Knee and Total Hip Arthroplasty: A Systematic Review and Meta-analysis.Archives of Iranian medicine · 2025Pooled it
- Update on metformin for osteoarthritis treatment.Inflammopharmacology · 2025Review
- Prior hip arthroscopy impacts long-term outcomes of total hip arthroplasty : a propensity-matched study with a minimum ten-year follow-up.Bone & joint open · 2025Article
- Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis.Clinical, cosmetic and investigational dermatology · 2025Article
- Association between the Body Roundness Index and osteoarthritis: A population-based study.PloS one · 2025Article
- Phenome-wide causal associations between osteoarthritis and other complex traits through the latent causal variable analysis.BMC musculoskeletal disorders · 2024Article
- The causal relationship between osteoarthritis and bladder cancer: A Mendelian randomization study.Cancer medicine · 2024Article
- The common link between sleep apnea syndrome and osteoarthritis: a literature review.Frontiers in medicine · 2024Review
- Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases.Scientific reports · 2023Article
- Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the causal association between genetically predicted obesity and the risk of hip osteoarthritis.
methodsWe performed two-sample Mendelian randomization (MR) analysis to analyze the association between body mass index (BMI) and hip osteoarthritis using pooled-level genome-wide association study (GWAS) data. The inverse variance weighted (IVW), MR‒Egger, and weighted median methods were used to estimate the causal association. In addition, we applied the MR Steiger filtering method, MR robust adjusted profile score (MR.RAPS) methods, and the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to examine and address potential horizontal pleiotropy.
resultsWe found a causal relationship between genetically predicted BMI and the risk of hip osteoarthritis by the IVW method [OR = 1.45, 95% confidence interval (CI) = 1.04-2.00, P = 0.02]. In the sensitivity analysis, the results of the MR‒Egger and weighted median methods revealed similar estimations but with a wide CI with lower precision. The funnel plot, MR-Egger intercept, and MR-PRESSO all indicated the absence of a directional pleiotropic effect. In addition, no heterogeneity was observed in the present analysis. Therefore, the result of IVW is most suitable and reliable for the present MR analysis.
conclusionThere is a causal relationship between obesity and a higher risk of hip osteoarthritis, suggesting that weight management may be an intervention for the prevention and management of hip osteoarthritis. LEVEL OF EVIDENCE: Bioinformatics, Basic science.
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