ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2023
Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- State-of-the-Art Review: Contemporary Ambulatory Approach to Adult Fever of Unknown Origin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Review
- Long-Term Follow-Up of Patients With Classic Fever of Unknown Origin: Prognostic Outcomes and Management Strategies.Open forum infectious diseases · 2026Article
- Diagnostic value of basic and extended procedures in pediatric fever of unknown origin - results of a nation-wide surveillance study.Molecular and cellular pediatrics · 2026Article
- Follow-up, diagnosis, and outcomes of fever of unknown origin cases in whom no diagnosis was established after initial evaluation: an ID-IRI (Infectious Diseases - International Research Initiative) observational retrospective cohort study.BMC infectious diseases · 2026Observational
- Patient representation in RNA signature studies for detecting and predicting the outcomes of febrile illnesses: a scoping review.BMC infectious diseases · 2026Article
- When Fever Defies Diagnosis: Wissler-Fanconi Syndrome as an Atypical Presentation of Adult-Onset Still's Disease.Clinical case reports · 2026Article
- Article
- Institutional Readiness and Diagnostic Challenges for the Management of Pyrexia of Unknown Origin (PUO) in Nepal: A Mixed-Methods Study at Tertiary Level Hospitals.Research square · 2026Article
- Fever of unknown origin: cost of illness study.Open medicine (Warsaw, Poland) · 2026Article
- Fever of unknown origin, muscle weakness, and an adrenal nodule-the cat we chased like a hare: a case report.Journal of medical case reports · 2025Article
- Fever of unknown origin (FUO): a 7-year clinical experience, etiological distribution, and diagnostic approaches.BMC infectious diseases · 2025Article
- Diagnostic Challenges in Pediatric Fever of Unknown Origin: Combined Role of Ferritin and Fever Duration.Children (Basel, Switzerland) · 2025Article
- Role ofJournal of clinical medicine · 2025Review
- Observational
- Article
- Droplet digital PCR aids in the diagnosis of children with fever of unknown origin --A typical case report.Heliyon · 2024Article
- [American journal of nuclear medicine and molecular imaging · 2024Review
- Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study.Journal of intensive medicine · 2024Article
- Clinicopathological profile of peritoneal tuberculosis and a new scoring model for predicting mortality: an international ID-IRI study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Review
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Abstract
Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development. The data of FUO patients hospitalized/followed between 1st July 2016 and 1st July 2021 were collected retrospectively and submitted from referral centers in 21 countries through ID-IRI clinical research platform. The countries were categorized into developing (low-income (LI) and lower middle-income (LMI) economies) and developed countries (upper middle-income (UMI) and high-income (HI) economies). This research included 788 patients. FUO diagnoses were as follows: infections (51.6%; n = 407), neoplasms (11.4%, n = 90), collagen vascular disorders (9.3%, n = 73), undiagnosed (20.1%, n = 158), miscellaneous diseases (7.7%, n = 60). The most common infections were tuberculosis (n = 45, 5.7%), brucellosis (n = 39, 4.9%), rickettsiosis (n = 23, 2.9%), HIV infection (n = 20, 2.5%), and typhoid fever (n = 13, 1.6%). Cardiovascular infections (n = 56, 7.1%) were the most common infectious syndromes. Only collagen vascular disorders were reported significantly more from developed countries (RR = 2.00, 95% CI: 1.19-3.38). FUO had similar characteristics in LI/LMI and UMI/HI countries including the portion of undiagnosed cases (OR, 95% CI; 0.87 (0.65-1.15)), death attributed to FUO (RR = 0.87, 95% CI: 0.65-1.15, p-value = 0.3355), and the mean duration until diagnosis (p = 0.9663). Various aspects of FUO cannot be determined by the economic development solely. Other development indices can be considered in future analyses. Physicians in different countries should be equally prepared for FUO patients.
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