Evidence map›Paper›PMID 36790491›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2023

Cerebrospinal fluid leakage after intradural spinal surgery in children.

Emma M H Slot, Tristan P C van Doormaal, Kirsten M van Baarsen, Niklaus Krayenbühl, Luca Regli, Menno R Germans, Eelco W Hoving

Open access · hybridAbstract read
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Perioperative risk factors predicting CSF leak and retethering following tethered cord release for complex spinal lipomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Emma M H SlotDepartment of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands. e.m.h.slot-4@umcutrecht.nl.
Tristan P C van DoormaalDepartment of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Kirsten M van BaarsenDepartment of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Niklaus KrayenbühlDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Luca RegliDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Menno R GermansDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Eelco W HovingDepartment of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.
University Hospital of Zurich · CHPrincess Máxima Center · NLUniversity Children's Hospital Zurich · CHUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to establish the incidence of CSF leakage in children and associated complications after intradural spinal surgery in three tertiary neurosurgical referral centers and to describe the treatment strategies applied.

methodsPatients of 18 years or younger who underwent intradural spinal surgery between 2015 and 2021 in three tertiary neurosurgical referral centers were included. Patients who died or were lost to follow-up within six weeks after surgery were excluded. The primary outcome measure was CSF leakage within six weeks after surgery, defined as leakage of CSF through the skin. Secondary outcome measures included the presence of pseudomeningocele (PMC), meningitis, and surgical site infection (SSI).

resultsWe included a total of 75 procedures, representing 66 individual patients. The median age in this cohort was 5 (IQR = 0-13 years. CSF leakage occurred in 2.7% (2/75) of procedures. It occurred on days 3 and 21 after the index procedure, respectively. One patient was treated with a pressure bandage and an external lumbar drain on day 4 after diagnosis of the leak, and the other was treated with wound revision surgery on day 1 after the leak occurred. In total, 1 patient developed a PMC without a CSF leak which was treated with wound revision surgery. SSI occurred in 10.7%, which included both cases of CSF leak.

conclusionsCSF leakage after intradural spinal surgery in the pediatric population is relatively rare (2.7%). Nevertheless, the clinical consequences with respect to secondary complications such as infection and the necessity for invasive treatment are serious.

Indexed as

Cerebrospinal Fluid LeakCerebrospinal Fluid RhinorrheaAdolescentChildChild, PreschoolHumansInfantInfant, NewbornNeurosurgical ProceduresPostoperative ComplicationsReoperationRetrospective StudiesSurgical Wound InfectionCerebrospinal fluid leakageInfectionPediatricsSpina bifidaSpinal surgery

Identifiers

PMID36790491
PMCPMC10160141
OpenAlexW4320857590

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.