Evidence map›Paper›PMID 36790488›Full record

ReviewSeminars in immunopathology2023

Towards multiomic analysis of oral mucosal pathologies.

Jakob Einhaus, Xiaoyuan Han, Dorien Feyaerts, John Sunwoo, Brice Gaudilliere, Somayeh H Ahmad, Nima Aghaeepour, Karl Bruckman, David Ojcius, Christian M Schürch and 1 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jakob EinhausDepartment of Anesthesiology, Perioperative & Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3450-4325
Xiaoyuan HanArthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA, USA.ORCID 0000-0001-6394-3055
Dorien FeyaertsDepartment of Anesthesiology, Perioperative & Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0795-6625
John SunwooDivision of Head and Neck Surgery, Department of Otolaryngology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8393-4196
Brice GaudilliereDepartment of Anesthesiology, Perioperative & Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3475-5706
Somayeh H AhmadDivision of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, 770 Welch Road, Palo Alto, CA, 94304, USA.
Nima AghaeepourDepartment of Anesthesiology, Perioperative & Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Karl BruckmanDivision of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, 770 Welch Road, Palo Alto, CA, 94304, USA.ORCID 0000-0002-3508-8191
David OjciusArthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA, USA.ORCID 0000-0003-1461-4495
Christian M SchürchDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany.ORCID 0000-0002-1792-1768
Dyani K GaudilliereDivision of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, 770 Welch Road, Palo Alto, CA, 94304, USA. dyani00@stanford.edu.ORCID 0000-0003-3017-5939
Stanford University · USUniversity of the Pacific · USStanford Medicine · US

Funding

Identifying a Systemic Immune Signature of Periodontal Disease with Mass CytometryR21DE027728 · NIDCR · STANFORD UNIVERSITY · PI GAUDILLIERE, BRICE, GAUDILLIERE, DYANI · 2018 to 2019
$432k
NIDCR NIH HHS R21 DE027728
6 · The paper itself

Abstract

Oral mucosal pathologies comprise an array of diseases with worldwide prevalence and medical relevance. Affecting a confined space with crucial physiological and social functions, oral pathologies can be mutilating and drastically reduce quality of life. Despite their relevance, treatment for these diseases is often far from curative and remains vastly understudied. While multiple factors are involved in the pathogenesis of oral mucosal pathologies, the host's immune system plays a major role in the development, maintenance, and resolution of these diseases. Consequently, a precise understanding of immunological mechanisms implicated in oral mucosal pathologies is critical (1) to identify accurate, mechanistic biomarkers of clinical outcomes; (2) to develop targeted immunotherapeutic strategies; and (3) to individualize prevention and treatment approaches. Here, we review key elements of the immune system's role in oral mucosal pathologies that hold promise to overcome limitations in current diagnostic and therapeutic approaches. We emphasize recent and ongoing multiomic and single-cell approaches that enable an integrative view of these pathophysiological processes and thereby provide unifying and clinically relevant biological signatures.

Indexed as

MultiomicsQuality of LifeBiomarkersHumansBiomarkersCytomicsImmunologyMass cytometryMetabolomicsMicrobiomeMultiomicsOral pathologyProteomicsTranscriptomics

Identifiers

PMID36790488
PMCPMC9974703
OpenAlexW4320857780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.