Evidence map›Paper›PMID 36790480›Full record

ArticleVirchows Archiv : an international journal of pathology2023

Colorectal adenosquamous carcinoma: genomic profiling of a rare histotype of colorectal cancer.

Valentina Angerilli, Paola Parente, Gianluca Businello, Alessandro Vanoli, Michele Paudice, Giovanni Perrone, Giada Munari, Ilaria Govoni, Giuseppe Neri, Elena Rebellato and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Valentina AngerilliDepartment of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua, PD, Italy.
Paola ParentePathology Unit, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, FG, Italy.
Gianluca BusinelloDepartment of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua, PD, Italy.
Alessandro VanoliDepartment of Molecular Medicine, Anatomic Pathology Unit, University of Pavia, Viale Camillo Golgi, 19, 27100, Pavia, PV, Italy. alessandro.vanoli@unipv.it.
Michele PaudiceOspedale Policlinico San Martino IRCCS, Genoa, GE, Italy.
Giovanni PerronePathology Unit, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, FG, Italy.
Giada MunariVeneto Institute of Oncology IOV - IRCCS, Padua, PD, Italy.
Ilaria GovoniDepartment of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua, PD, Italy.
Giuseppe NeriDepartment of Molecular Medicine, Anatomic Pathology Unit, University of Pavia, Viale Camillo Golgi, 19, 27100, Pavia, PV, Italy.
Elena RebellatoDepartment of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua, PD, Italy.
Paola ParrellaLaboratory of Oncology, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, FG, Italy.
Federica GrilloOspedale Policlinico San Martino IRCCS, Genoa, GE, Italy.
Luca MastracciOspedale Policlinico San Martino IRCCS, Genoa, GE, Italy.
Matteo FassanDepartment of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua, PD, Italy. matteo.fassan@unipd.it.ORCID http://orcid.org/0000-0001-6515-5482

Funding

Associazione Italiana per la Ricerca sul Cancro AIRC 5 per mille 2019 (ID. 22759 program)Regione del Veneto NET-2016-02363853
6 · The paper itself

Abstract

Colorectal adenosquamous carcinoma (ASC) is exceedingly rare, comprising less than 0.1% of all colorectal malignancies, and is characterized by an aggressive disease course, with a higher metastatic rate and worse outcome than conventional colorectal adenocarcinoma. A comprehensive molecular profile of this group of neoplasms is still lacking. A total of 22 cases of colorectal ASCs (with 22 primary lesions and 7 metastases matched with 4 primaries) were subject to NGS targeting 67 cancer-related genes (VariantPlex solid tumor; Archer). Mismatch repair (MMR), p53, and

Indexed as

Carcinoma, AdenosquamousColorectal NeoplasmsDNA Copy Number VariationsGenomicsHumansMutationProto-Oncogene Proteins B-rafProto-Oncogene Proteins B-rafAdenosquamous carcinomaColorectal carcinomaNext-generation sequencing

Identifiers

PMID36790480
PMCPMC10156896

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.