Evidence map›Paper›PMID 36790289›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2023

Changes of antioxidant enzymes in the kidney after cardiac arrest in the rat model.

J H Lee, M S Islam, Y J Yoo, S E Kim, R H Kim, Y J Jang, S H Lee, H P Hwang, H Y Shin, J H Hwang and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

J H LeeDepartment of Anesthesiology and Pain Medicine, Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea.ORCID http://orcid.org/0000-0002-9424-8589
M S IslamDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0002-1133-559X
Y J YooDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0002-3865-7599
S E KimDepartment of Emergency Medicine, Research Institute of Clinical Medicine, Jeonbuk National University and Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea.ORCID http://orcid.org/0000-0001-8714-3554
R H KimDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0002-9803-9178
Y J JangDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0002-0898-373X
S H LeeDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0002-2865-6816
H P HwangDepartment of Surgery, Jeonbuk National University Medical School and Hospital, Jeonju, Korea.ORCID http://orcid.org/0000-0003-3489-7883
H Y ShinAnimal Model Research Group, Jeonbuk Branch Institute, Korea Institute of Toxicology, Jeongup, Jeonbuk, Korea.ORCID http://orcid.org/0000-0002-0901-4826
J H HwangAnimal Model Research Group, Jeonbuk Branch Institute, Korea Institute of Toxicology, Jeongup, Jeonbuk, Korea.ORCID http://orcid.org/0000-0002-4763-8373
K KimDepartment of Thoracic and Cardiovascular Surgery, Research Institute of Clinical Medicine, Jeonbuk National University-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea.ORCID http://orcid.org/0000-0002-9417-0769
B Y ParkDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0001-8897-2258
D AhnDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0002-7024-1606
Y LeeDepartment of Anesthesiology and Pain Medicine, Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea.ORCID http://orcid.org/0000-0002-1857-2002
T KimDepartment of Anesthesiology and Pain Medicine, Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea.ORCID http://orcid.org/0000-0002-2927-7236
I S KimDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0003-1767-5795
J C YoonDepartment of Anesthesiology and Pain Medicine, Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea.ORCID http://orcid.org/0000-0001-8781-9622
H J TaeDepartment of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, Jeollabuk-do, Korea.ORCID http://orcid.org/0000-0002-5193-508X
Jeonbuk National University · KRJeonbuk National University Hospital · KRKorea Institute of Toxicology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, cardiac arrest (CA) is a leading cause of death and disability. Asphyxial CA (ACA)-induced kidney damage is a crucial factor in reducing the survival rate. The purpose of this study was to investigate the role of antioxidant enzymes in histopathological renal damage in an ACA rat model at different time points. A total of 88 rats were divided into five groups and exposed to ACA except for the sham group. To evaluate glomerular function and oxidative stress, serum levels of blood urea nitrogen (BUN) and creatinine (Crtn) and malondialdehyde (MDA) levels in renal tissues were measured. To determine histopathological damage, hematoxylin and eosin staining, periodic acid-Schiff staining, and Masson's trichrome staining were performed. Expression levels of antioxidant enzymes including superoxide dismutase-1 (SOD-1), superoxide dismutase-2 (SOD-2), catalase (CAT), and glutathione peroxidase (GPx) were measured by immunohistochemistry (IHC). Survival rate of the experimental rats was reduced to 80% at 6 h, 55% at 12 h, 42.9% at 1 day, and 33% at 2 days after return of spontaneous circulation. Levels of BUN, Crtn, and MDA started to increase significantly in the early period of CA induction. Renal histopathological damage increased markedly from 6 h until two days post-CA. Additionally, expression levels of antioxidant enzymes were significantly decreased at 6 h, 12 h, 1 day, and 2 days after CA. CA-induced oxidative stress and decreased levels of antioxidant enzymes (SOD-1, SOD-2, CAT, GPx) from 6 h to two days could be possible mediators of severe renal tissue damage and increased mortality rate.

Indexed as

AntioxidantsKidney DiseasesAnimalsCatalaseGlutathione PeroxidaseKidneyMalondialdehydeOxidative StressRatsSuperoxide DismutaseAntioxidantsCatalaseGlutathione PeroxidaseMalondialdehydeSuperoxide Dismutase

Identifiers

PMID36790289
PMCPMC9925192
OpenAlexW4320017937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.